FGR

GENE INFORMATION

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Gene name

FGR (HGNC Symbol)

Synonyms

c-fgr, p55c-fgr, SRC2

Description

feline Gardner-Rasheed sarcoma viral oncogene homolog (HGNC Symbol)

Entrez gene summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p36.11

Chromosome location (bp)

27938575 - 27961788

Ensembl

ENSG00000000938 (version 73.37)

Entrez gene

2268

UniProt

P09769 (UniProt - Evidence at protein level)

neXtProt

NX_P09769

Antibodypedia

FGR antibodies
 

PROTEIN VIEW

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FGR-001
 
FGR-002
 
FGR-004
 
FGR-007
 
FGR-201
 
FGR-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FGR-001 ENSP00000363117
ENST00000374005
P09769
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Show » Show » 529 59.5 No 0
FGR-002 ENSP00000363115
ENST00000374003
P09769
Show all »
Show » Show » 529 59.5 No 0
FGR-004 ENSP00000363116
ENST00000374004
P09769
Show all »
Show » Show » 529 59.5 No 0
FGR-007 ENSP00000407670
ENST00000457296
Q5TGY6
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Show » Show » 313 34.7 No 0
FGR-201 ENSP00000382126
ENST00000399173
P09769
Show all »
Show » Show » 529 59.5 No 0
FGR-202 ENSP00000445302
ENST00000545953
F5H3M4
Show all »
Show » Show » 463 52.2 No 0