The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Distinct staining of extracellular matrix in several malignant tissues, virtually no staining in other cellular compartments.
Cases of hepatocellular carcinomas displayed moderate cytoplasmic positivity while fractions of cells in renal cancers showed nuclear positivity. Malignant cells in general were negative.
A few cases of hepatocellular carcinomas, colorectal, breast, testicular and urothelial cancers along with occasional cases of renal cancers and malignant melanomas showed weak to moderate cytoplasmic positivity. Remaining malignant cells were negative.
Validation
Two (or more) antibodies yielding similar staining patterns which are consistent with available gene/protein characterization data
Two (or more) antibodies yielding similar staining patterns which are consistent with available gene/protein characterization data
The multi-targeting antibody yielding a staining pattern consistent with gene/protein characterization data for all of the genes
