GCLC

GENE INFORMATION

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Gene name

GCLC (HGNC Symbol)

Synonyms

GCS, GLCL, GLCLC

Description

Glutamate-cysteine ligase, catalytic subunit (HGNC Symbol)

Entrez gene summary

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]

Chromosome

6

Cytoband

p12.1

Chromosome location (bp)

53362139 - 53481768

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000001084 (version 75.37)

Entrez gene

2729

UniProt

P48506 (UniProt - Evidence at protein level)

neXtProt

NX_P48506

Antibodypedia

GCLC antibodies
 

PROTEIN VIEW

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GCLC-001
 
GCLC-003
 
GCLC-006
 
GCLC-007
 
GCLC-008
 
GCLC-009
 
GCLC-010
 
GCLC-013
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GCLC-001 ENSP00000229416
ENST00000229416
P48506
Show all »
Show » Show » 637 72.8 No 0
GCLC-003 ENSP00000421908
ENST00000514004
P48506
Show all »
Show » Show » 252 28.8 No 0
GCLC-006 ENSP00000423615
ENST00000514933
D6R959
Show all »
Show » Show » 154 17.4 No 0
GCLC-007 ENSP00000421629
ENST00000505294
D6REX4
Show all »
Show » Show » 122 13.9 No 0
GCLC-008 ENSP00000421228
ENST00000504525
D6RGF8
Show all »
Show » Show » 54 6.4 No 0
GCLC-009 ENSP00000424211
ENST00000513939
Show » 173 20.1 No 0
GCLC-010 ENSP00000426578
ENST00000514373
Show » Show » 94 11 No 2
GCLC-013 ENSP00000427403
ENST00000505197
Show » 18 2.1 No 0