CD99

GENERAL INFORMATION

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Gene name

CD99

Gene description

CD99 molecule

Protein class

CD markers
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Membranous expression most abundant in islets of Langerhans, cells in seminiferous ducts and subsets of lymphoid cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA035304 , CAB000020
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CD99 (HGNC Symbol)

Synonyms

MIC2

Description

CD99 molecule (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2013]

Chromosome

X

Cytoband

p22.33

Chromosome location (bp)

2691179 - 2741309

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000002586 (version 78.38)

Entrez gene

4267

UniProt

P14209 (UniProt - Evidence at protein level)

neXtProt

NX_P14209

Antibodypedia

CD99 antibodies


PROTEIN BROWSER

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ENST00000381180
 
ENST00000381184
 
ENST00000381187
 
ENST00000381192
 
ENST00000449611
 
ENST00000611428
 
ENST00000624481
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD99-001 ENSP00000370588
ENST00000381192
P14209
Show all »
Show » Show » 185 18.8 Yes 1
CD99-002 ENSP00000370573
ENST00000381180
A6NJT9
Show all »
Show » 76 8 Yes 0
CD99-003 ENSP00000370582
ENST00000381187
P14209
Show all »
Show » Show » 169 17.1 Yes 1
CD99-004 ENSP00000370579
ENST00000381184
A8MQT7
Show all »
Show » 177 17.7 Yes 1
CD99-005 ENSP00000405544
ENST00000449611
H7C2F2
Show all »
Show » 201 20.6 No 1
CD99-010 ENSP00000485427
ENST00000624481
Show » 184 18.8 Yes 1
CD99-201 ENSP00000479999
ENST00000611428
P14209
Show all »
Show » Show » 160 16 Yes 1