CASP10

GENE INFORMATION

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Gene name

CASP10 (HGNC Symbol)

Synonyms

MCH4

Description

caspase 10, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

Chromosome

2 (Chromosome progress)

Cytoband

q33.1

Chromosome location (bp)

202047604 - 202094129

Ensembl

ENSG00000003400 (version 73.37)

Entrez gene

843

UniProt

Q92851 (UniProt - Evidence at protein level)

neXtProt

NX_Q92851

Antibodypedia

CASP10 antibodies
 

PROTEIN VIEW

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CASP10-001
 
CASP10-002
 
CASP10-003
 
CASP10-006
 
CASP10-007
 
CASP10-009
 
CASP10-010
 
CASP10-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASP10-001 ENSP00000286186
ENST00000286186
Q92851
Show all »
Show » Show » 522 59 No 0
CASP10-002 ENSP00000272879
ENST00000272879
Q92851
Show all »
Show » Show » 521 59 No 0
CASP10-003 ENSP00000237865
ENST00000346817
Q92851
Show all »
Show » Show » 479 54.6 No 0
CASP10-006 ENSP00000401914
ENST00000438843
B4E3T5
Show all »
Show » 118 13.7 No 0
CASP10-007 ENSP00000363781
ENST00000374650
Q68HC0
Show all »
Show » 247 28.4 No 0
CASP10-009 ENSP00000314599
ENST00000313728
Q92851
Show all »
Show » Show » 455 51.8 No 0
CASP10-010 ENSP00000396835
ENST00000448480
Q92851
Show all »
Show » Show » 478 54.5 No 0
CASP10-201 ENSP00000353250
ENST00000360132
Q92851
Show all »
Show » Show » 273 31.4 No 0