AK2

GENE INFORMATION

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Gene name

AK2

Synonyms

Description

adenylate kinase 2 (HGNC Symbol)

Entrez gene summary

Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]

Chromosome

1 (Chromosome progress)

Cytoband

p35.1

Chromosome location (bp)

33473585 - 33546597

Ensembl

ENSG00000004455 (version 73.37)

Entrez gene

204

UniProt

P54819 (UniProt - Evidence at protein level)

neXtProt

NX_P54819

Antibodypedia

AK2 antibodies
 

PROTEIN VIEW

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AK2-001
 
AK2-002
 
AK2-003
 
AK2-007
 
AK2-009
 
AK2-010
 
AK2-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AK2-001 ENSP00000346921
ENST00000354858
P54819
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Show » Show » 239 26.5 No 0
AK2-002 ENSP00000362548
ENST00000373449
P54819
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Show » Show » 232 25.6 No 0
AK2-003 ENSP00000447082
ENST00000467905
F8W1A4
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Show » 232 25.6 No 0
AK2-007 ENSP00000446849
ENST00000487289
F8VZG5
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Show » 162 17.5 No 0
AK2-009 ENSP00000450109
ENST00000480134
G3V213
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Show » 133 14.3 No 0
AK2-010 ENSP00000449003
ENST00000548033
F8VY04
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Show » 190 21.2 No 0
AK2-011 ENSP00000450008
ENST00000550338
F8VPP1
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42 4.5 No 0