FKBP4

GENE INFORMATION

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Gene name

FKBP4 (HGNC Symbol)

Synonyms

FKBP52, FKBP59

Description

FK506 binding protein 4, 59kDa (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]

Chromosome

12 (Chromosome progress)

Cytoband

p13.33

Chromosome location (bp)

2904119 - 2914576

Ensembl

ENSG00000004478 (version 73.37)

Entrez gene

2288

UniProt

Q02790 (UniProt - Evidence at protein level)

neXtProt

NX_Q02790

Antibodypedia

FKBP4 antibodies
 

PROTEIN VIEW

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FKBP4-001
 
FKBP4-002
 
FKBP4-004
 
FKBP4-006
 
FKBP4-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FKBP4-001 ENSP00000001008
ENST00000001008
Q02790
Show all »
Show » Show » 459 51.8 No 0
FKBP4-002 ENSP00000439703
ENST00000543769
F5H120
Show all »
51 5.5 No 0
FKBP4-004 ENSP00000446368
ENST00000538622
F5H1U3
Show all »
Show » 86 9.5 No 0
FKBP4-006 ENSP00000438491
ENST00000539181
Show » 84 9.5 No 0
FKBP4-007 ENSP00000442193
ENST00000544366
23 2.5 No 0