UPF1

GENE INFORMATION

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Gene name

UPF1 (HGNC Symbol)

Synonyms

HUPF1, KIAA0221, NORF1, pNORF1, RENT1, smg-2

Description

UPF1 regulator of nonsense transcripts homolog (yeast) (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

p13.11

Chromosome location (bp)

18942747 - 18979045

Ensembl

ENSG00000005007 (version 73.37)

Entrez gene

5976

UniProt

Q92900 (UniProt - Evidence at protein level)

neXtProt

NX_Q92900

Antibodypedia

UPF1 antibodies
 

PROTEIN VIEW

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UPF1-001
 
UPF1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UPF1-001 ENSP00000262803
ENST00000262803
Q92900
Show all »
Show » 1118 123 No 0
UPF1-002 ENSP00000470142
ENST00000599848
Q92900
Show all »
Show » 1129 124.3 No 0