CREBBP

GENE INFORMATION

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Gene name

CREBBP (HGNC Symbol)

Synonyms

CBP, KAT3A, RSTS, RTS

Description

CREB binding protein (HGNC Symbol)

Entrez gene summary

This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]

Chromosome

16 (Chromosome progress)

Cytoband

p13.3

Chromosome location (bp)

3775055 - 3930727

Ensembl

ENSG00000005339 (version 73.37)

Entrez gene

1387

UniProt

Q92793 (UniProt - Evidence at protein level)

neXtProt

NX_Q92793

Antibodypedia

CREBBP antibodies
 

PROTEIN VIEW

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CREBBP-001
 
CREBBP-003
 
CREBBP-005
 
CREBBP-006
 
CREBBP-008
 
CREBBP-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CREBBP-001 ENSP00000262367
ENST00000262367
Q92793
Show all »
Show » Show » 2442 265.4 No 0
CREBBP-003 ENSP00000371502
ENST00000382070
Q92793
Show all »
Show » Show » 2404 261 No 0
CREBBP-005 ENSP00000458254
ENST00000572134
B5A252
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Show » Show » 254 27.2 No 0
CREBBP-006 ENSP00000459490
ENST00000571826
Show » 181 19 No 0
CREBBP-008 ENSP00000461002
ENST00000570939
B5A244
Show all »
Show » Show » 288 33.4 No 0
CREBBP-011 ENSP00000460474
ENST00000573517
I3L3I5
Show all »
Show » Show » 195 22.5 No 0