ABCB4

GENE INFORMATION

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Gene name

ABCB4 (HGNC Symbol)

Synonyms

GBD1, MDR2, MDR3, PFIC-3, PGY3

Description

ATP-binding cassette, sub-family B (MDR/TAP), member 4 (HGNC Symbol)

Entrez gene summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008]

Chromosome

7 (Chromosome progress)

Cytoband

q21.12

Chromosome location (bp)

87031013 - 87109751

Ensembl

ENSG00000005471 (version 73.37)

Entrez gene

5244

UniProt

P21439 (UniProt - Evidence at protein level)

neXtProt

NX_P21439

Antibodypedia

ABCB4 antibodies
 

PROTEIN VIEW

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ABCB4-001
 
ABCB4-002
 
ABCB4-003
 
ABCB4-008
 
ABCB4-009
 
ABCB4-201
 
ABCB4-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCB4-001 ENSP00000352135
ENST00000359206
P21439
Show all »
Show » Show » 1279 140.7 No >9
ABCB4-002 ENSP00000265723
ENST00000265723
P21439
Show all »
Show » Show » 1286 141.5 No >9
ABCB4-003 ENSP00000394511
ENST00000417608
E7EQI1
Show all »
Show » 61 6.9 No 0
ABCB4-008 ENSP00000395716
ENST00000440025
99 11.1 No 0
ABCB4-009 ENSP00000392983
ENST00000453593
P21439
Show all »
Show » Show » 1232 135.3 No >9
ABCB4-201 ENSP00000351172
ENST00000358400
P21439
Show all »
Show » Show » 1232 135.3 No >9
ABCB4-202 ENSP00000437465
ENST00000545634
P21439
Show all »
Show » Show » 1279 140.7 No >9