ITGA2B

GENE INFORMATION

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Gene name

ITGA2B (HGNC Symbol)

Synonyms

CD41, CD41B, GP2B

Description

integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) (HGNC Symbol)

Entrez gene summary

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q21.31

Chromosome location (bp)

42449548 - 42466873

Ensembl

ENSG00000005961 (version 73.37)

Entrez gene

3674

UniProt

P08514 (UniProt - Evidence at protein level)

neXtProt

NX_P08514

Antibodypedia

ITGA2B antibodies
 

PROTEIN VIEW

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ITGA2B-001
 
ITGA2B-011
 
ITGA2B-012
 
ITGA2B-201
 
ITGA2B-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ITGA2B-001 ENSP00000262407
ENST00000262407
P08514
Show all »
Show » Show » 1039 113.4 Yes 1
ITGA2B-011 ENSP00000467269
ENST00000587295
104 11.4 No 0
ITGA2B-012 ENSP00000465534
ENST00000588098
32 3.5 No 0
ITGA2B-201 ENSP00000340536
ENST00000353281
P08514
Show all »
Show » Show » 1005 109.6 Yes 1
ITGA2B-202 ENSP00000366268
ENST00000377068
B7Z8B0
Show all »
Show » 219 23.1 No 0