The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
Annotated protein expressioni
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Most normal tissues displayed weak to moderate cytoplasmic and/or nuclear positivity. Strong membranous and/or cytoplasmic staining was observed in the gastrointestinal tract, gall bladder and throphoblastic cells while urinary bladder and neuronal cells in CNS showed strong nuclear positivity.
Normal cells showed moderate to strong cytoplasmic positivity. Cardiac myocytes were weakly stained.
Normal tissues showed weak to moderate cytoplasmic and membranous staining. Gastrointestinal tract, urothelium, gall bladder, ovarian follicles and prostate glands displayed strong membranous positivity.
A majority of the normal tissues displayed moderate cytoplasmic and occasional membranous positivity. Strong staining was observed in the gastrointestinal tract, hepatocytes, ovarian follicles and prostate. Alveolar cells, glial cells and lymphoid tissues were weakly stained or negative.