BAIAP2L1

GENE INFORMATION

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Gene name

BAIAP2L1 (HGNC Symbol)

Synonyms

IRTKS

Description

BAI1-associated protein 2-like 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009]

Chromosome

7 (Chromosome progress)

Cytoband

q21.3

Chromosome location (bp)

97920963 - 98030380

Ensembl

ENSG00000006453 (version 73.37)

Entrez gene

55971

UniProt

Q9UHR4 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UHR4

Antibodypedia

BAIAP2L1 antibodies
 

PROTEIN VIEW

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BAIAP2L1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BAIAP2L1-001 ENSP00000005260
ENST00000005260
Q9UHR4
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