ELAC2

GENE INFORMATION

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Gene name

ELAC2 (HGNC Symbol)

Synonyms

FLJ10530, HPC2

Description

elaC ribonuclease Z 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

17 (Chromosome progress)

Cytoband

p12

Chromosome location (bp)

12895708 - 12921504

Ensembl

ENSG00000006744 (version 73.37)

Entrez gene

60528

UniProt

Q9BQ52 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BQ52

Antibodypedia

ELAC2 antibodies
 

PROTEIN VIEW

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ELAC2-001
 
ELAC2-002
 
ELAC2-007
 
ELAC2-009
 
ELAC2-012
 
ELAC2-013
 
ELAC2-016
 
ELAC2-017
 
ELAC2-020
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ELAC2-001 ENSP00000337445
ENST00000338034
Q9BQ52
Show all »
Show » Show » 826 92.2 No 0
ELAC2-002 ENSP00000379291
ENST00000395962
G5E9D5
Show all »
Show » 807 90 No 0
ELAC2-007 ENSP00000406192
ENST00000446899
286 31.7 No 0
ELAC2-009 ENSP00000463884
ENST00000476042
45 4.8 No 0
ELAC2-012 ENSP00000405223
ENST00000426905
Q9BQ52
Show all »
Show » Show » 786 87.6 No 0
ELAC2-013 ENSP00000463740
ENST00000584650
Q9HAS7
Show all »
Show » 626 70.1 No 0
ELAC2-016 ENSP00000464358
ENST00000583371
J3QRS2
Show all »
Show » 122 13.9 No 0
ELAC2-017 ENSP00000463321
ENST00000581499
J3QRS2
Show all »
Show » 132 15 No 0
ELAC2-020 ENSP00000463594
ENST00000580504
J3QLK4
Show all »
Show » 148 16.5 No 0