MATK

GENE INFORMATION

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Gene name

MATK (HGNC Symbol)

Synonyms

CHK, CTK, DKFZp434N1212, HHYLTK, HYL, HYLTK, Lsk, MGC1708, MGC2101

Description

megakaryocyte-associated tyrosine kinase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

p13.3

Chromosome location (bp)

3777971 - 3802127

Ensembl

ENSG00000007264 (version 73.37)

Entrez gene

4145

UniProt

P42679 (UniProt - Evidence at protein level)

neXtProt

NX_P42679

Antibodypedia

MATK antibodies
 

PROTEIN VIEW

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MATK-001
 
MATK-002
 
MATK-003
 
MATK-004
 
MATK-005
 
MATK-006
 
MATK-007
 
MATK-008
 
MATK-009
 
MATK-010
 
MATK-011
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MATK-001 ENSP00000378485
ENST00000395045
P42679
Show all »
Show » Show » 508 56.8 No 0
MATK-002 ENSP00000378481
ENST00000395040
P42679
Show all »
Show » Show » 466 51.9 No 0
MATK-003 ENSP00000308734
ENST00000310132
P42679
Show all »
Show » Show » 507 56.5 No 0
MATK-004 ENSP00000468030
ENST00000585778
K7EQY5
Show all »
Show » Show » 506 56.3 No 0
MATK-005 ENSP00000467992
ENST00000590849
K7EQV3
Show all »
Show » Show » 84 9.5 No 0
MATK-006 ENSP00000467006
ENST00000590028
K7ENL8
Show all »
Show » Show » 174 19.6 No 0
MATK-007 ENSP00000465556
ENST00000591059
13 1.4 No 0
MATK-008 ENSP00000468465
ENST00000587180
K7ERY4
Show all »
Show » Show » 131 14.8 No 0
MATK-009 ENSP00000465761
ENST00000588983
K7EKS5
Show all »
Show » Show » 237 26.2 No 0
MATK-010 ENSP00000468576
ENST00000590493
K7ES68
Show all »
Show » Show » 267 29.8 No 0
MATK-011 ENSP00000467472
ENST00000590980
K7EPP2
Show all »
38 4.3 No 0