CDK11A

GENE INFORMATION

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Gene name

CDK11A (HGNC Symbol)

Synonyms

CDC2L2, CDC2L3, CDK11-p110, CDK11-p46, CDK11-p58, p58GTA, PITSLRE

Description

cyclin-dependent kinase 11A (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p36.33

Chromosome location (bp)

1634169 - 1655766

Ensembl

ENSG00000008128 (version 73.37)

Entrez gene

984

UniProt

Q9UQ88 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UQ88

Antibodypedia

CDK11A antibodies
 

PROTEIN VIEW

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 « 
 
CDK11A-001
 
CDK11A-002
 
CDK11A-003
 
CDK11A-004
 
CDK11A-005
 
CDK11A-007
 
CDK11A-008
 
CDK11A-011
 
CDK11A-026
 
CDK11A-027
 
CDK11A-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDK11A-001 ENSP00000384442
ENST00000404249
Q9UQ88
Show all »
Show » Show » 780 91 No 0
CDK11A-002 ENSP00000462289
ENST00000460465
J3KS35
Show all »
Show » 407 49 No 0
CDK11A-003 ENSP00000350403
ENST00000357760
Q5QPR3
Show all »
Show » 779 91 No 0
CDK11A-004 ENSP00000351629
ENST00000358779
Q9UQ88
Show all »
Show » Show » 770 90 No 0
CDK11A-005 ENSP00000367900
ENST00000378633
Q9UQ88
Show all »
Show » Show » 783 91.4 No 0
CDK11A-007 ENSP00000423900
ENST00000479362
E9PFJ2
Show all »
Show » 151 18.9 No 0
CDK11A-008 ENSP00000348529
ENST00000356200
Q5QPR4
Show all »
Show » 746 86.8 No 0
CDK11A-011 ENSP00000383874
ENST00000401096
Q5QPQ9
Show all »
Show » 37 4.6 No 0
CDK11A-026 ENSP00000422149
ENST00000509982
E7ESP2
Show all »
Show » 420 50.4 No 0
CDK11A-027 ENSP00000367905
ENST00000378638
Q5QPR4
Show all »
Show » 746 86.8 No 0
CDK11A-201 ENSP00000367902
ENST00000378635
G8JLH1
Show all »
Show » 232 27.9 No 0