ADAM22

GENE INFORMATION

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Gene name

ADAM22 (HGNC Symbol)

Synonyms

MDC2

Description

ADAM metallopeptidase domain 22 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]

Chromosome

7 (Chromosome progress)

Cytoband

q21.12

Chromosome location (bp)

87563458 - 87832204

Ensembl

ENSG00000008277 (version 73.37)

Entrez gene

53616

UniProt

Q9P0K1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9P0K1

Antibodypedia

ADAM22 antibodies
 

PROTEIN VIEW

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ADAM22-001
 
ADAM22-002
 
ADAM22-003
 
ADAM22-004
 
ADAM22-005
 
ADAM22-006
 
ADAM22-007
 
ADAM22-008
 
ADAM22-009
 
ADAM22-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAM22-001 ENSP00000265727
ENST00000265727
Q9P0K1
Show all »
Show » Show » 906 100.4 Yes 1
ADAM22-002 ENSP00000381267
ENST00000398209
Q9P0K1
Show all »
Show » Show » 899 100.3 Yes 1
ADAM22-003 ENSP00000381262
ENST00000398204
Q9P0K1
Show all »
Show » Show » 870 96.6 Yes 1
ADAM22-004 ENSP00000381260
ENST00000398201
Q9P0K1
Show all »
Show » Show » 859 95.3 Yes 1
ADAM22-005 ENSP00000396233
ENST00000426930
H7C0Q9
Show all »
Show » 330 36.1 No 1
ADAM22-006 ENSP00000412085
ENST00000413139
Show » 264 29.4 No 1
ADAM22-007 ENSP00000391334
ENST00000439864
E7EPF1
Show all »
Show » Show » 342 39.6 Yes 0
ADAM22-008 ENSP00000381261
ENST00000398203
F8WAD8
Show all »
Show » Show » 804 89.5 No 1
ADAM22-009 ENSP00000413899
ENST00000412441
E9PF78
Show all »
Show » 196 21.9 Yes 0
ADAM22-201 ENSP00000315900
ENST00000315984
G5E951
Show all »
Show » Show » 899 100.2 Yes 1