MMP25

GENERAL INFORMATION

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Gene name

MMP25

Gene description

Matrix metallopeptidase 25

Protein class

Enzymes
FDA approved drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (appendix, bone marrow, spleen)
GTEx:Tissue enriched (spleen)

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
CAB025177
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (appendix, bone marrow, spleen)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (spleen)

Organ

Expression



GENE INFORMATION

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Gene name

MMP25 (HGNC Symbol)

Synonyms

MMP20, MMPL1, MT6-MMP

Description

Matrix metallopeptidase 25 (HGNC Symbol)

Entrez gene summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

p13.3

Chromosome location (bp)

3046681 - 3060726

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000008516 (version 78.38)

Entrez gene

64386

UniProt

Q9NPA2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NPA2

Antibodypedia

MMP25 antibodies


PROTEIN BROWSER

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ENST00000336577
 
ENST00000612971
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP25-001 ENSP00000337816
ENST00000336577
Q9NPA2
Show all »
Show » Show » 562 62.6 Yes 0
MMP25-201 ENSP00000482854
ENST00000612971
O43923
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Show » Show » 183 20.4 No 0