MASP2

GENE INFORMATION

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Gene name

MASP2 (HGNC Symbol)

Synonyms

MASP1P1

Description

mannan-binding lectin serine peptidase 2 (HGNC Symbol)

Entrez gene summary

The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p36.22

Chromosome location (bp)

11086580 - 11107290

Ensembl

ENSG00000009724 (version 73.37)

Entrez gene

10747

UniProt

O00187 (UniProt - Evidence at protein level)

neXtProt

NX_O00187

Antibodypedia

MASP2 antibodies
 

PROTEIN VIEW

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MASP2-001
 
MASP2-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MASP2-001 ENSP00000383690
ENST00000400897
O00187
Show all »
Show » Show » 686 75.7 Yes 0
MASP2-002 ENSP00000383691
ENST00000400898
O00187
Show all »
Show » Show » 185 20.6 Yes 0