NISCH

GENE INFORMATION

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Gene name

NISCH (HGNC Symbol)

Synonyms

I-1, IRAS, KIAA0975

Description

Nischarin (HGNC Symbol)

Entrez gene summary

This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]

Chromosome

3

Cytoband

p21.1

Chromosome location (bp)

52489134 - 52527087

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000010322 (version 75.37)

Entrez gene

11188

UniProt

Q9Y2I1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y2I1

Antibodypedia

NISCH antibodies
 

PROTEIN VIEW

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NISCH-001
 
NISCH-004
 
NISCH-014
 
NISCH-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NISCH-001 ENSP00000418232
ENST00000479054
Q9Y2I1
Show all »
Show » Show » 1504 166.6 No 0
NISCH-004 ENSP00000417812
ENST00000488380
C9J715
Show all »
Show » Show » 583 64.1 No 0
NISCH-014 ENSP00000392484
ENST00000420808
Q9Y2I1
Show all »
Show » Show » 515 56.9 No 0
NISCH-201 ENSP00000339958
ENST00000345716
Q9Y2I1
Show all »
Show » Show » 1504 166.6 No 0