TCEB3

GENE INFORMATION

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Gene name

TCEB3 (HGNC Symbol)

Synonyms

SIII, TCEB3A

Description

transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) (HGNC Symbol)

Entrez gene summary

This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p36.11

Chromosome location (bp)

24069645 - 24088549

Ensembl

ENSG00000011007 (version 73.37)

Entrez gene

6924

UniProt

Q14241 (UniProt - Evidence at protein level)

neXtProt

NX_Q14241

Antibodypedia

TCEB3 antibodies
 

PROTEIN VIEW

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TCEB3-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TCEB3-001 ENSP00000395574
ENST00000418390
Q14241
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