The Human Protein Atlas

GENE INFORMATION

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Gene name	BRCA1 (HGNC Symbol)
Synonyms	BRCC1, PPP1R53, RNF53
Description	breast cancer 1, early onset (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
Chromosome	17 (Chromosome progress)
Cytoband	q21.31
Chromosome location (bp)	41196312 - 41322290
Ensembl	ENSG00000012048 (version 69.37)
Entrez gene	672
UniProt	P38398
neXtProt	NX_P38398
Antibodypedia	BRCA1 antibodies

PROTEIN VIEW

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BRCA1-001		BRCA1-002		BRCA1-003		BRCA1-004		BRCA1-005		BRCA1-006		BRCA1-007		BRCA1-008		BRCA1-009		BRCA1-010		BRCA1-011		BRCA1-013		BRCA1-014		BRCA1-015		BRCA1-016		BRCA1-017		BRCA1-018		BRCA1-019		BRCA1-020		BRCA1-022		BRCA1-023		BRCA1-024		BRCA1-025		BRCA1-026		BRCA1-201		BRCA1-202		BRCA1-203		BRCA1-204		BRCA1-205		BRCA1-206

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
BRCA1-001	ENSP00000350283 ENST00000357654	P38398 Show all » « Hide P38398 [Direct mapping] Breast cancer type 1 susceptibility protein E9PFZ0 [Target identity:97%; Query identity:100%] Breast cancer type 1 susceptibility protein Q3LRH8 [Target identity:97%; Query identity:100%] Breast cancer 1 early onset; Early onset breast cancer 1 E7EP70 [Target identity:84%; Query identity:100%] Breast cancer type 1 susceptibility protein; Uncharacterized protein E7EWN5 [Target identity:34%; Query identity:100%] Breast cancer type 1 susceptibility protein Q3B891 [Target identity:25%; Query identity:100%] BRCA1 protein; Breast cancer type 1 susceptibility protein Q7KYU6 [Target identity:12%; Query identity:100%] Breast and ovarian cancer susceptibility protein C9IZW4 [Target identity:9%; Query identity:100%] Breast cancer type 1 susceptibility protein Q4EW25 [Target identity:8%; Query identity:100%] Breast and ovarian cancer suseptibility protein variant E7EN90 [Target identity:3%; Query identity:100%] Breast cancer type 1 susceptibility protein G4V4Z7 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 G4V4Z8 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 G4V500 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 G4V502 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 G4V503 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 Q3YB49 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein Q3YB53 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein C4PFY7 [Target identity:1%; Query identity:100%] BRCA1 G1UI37 [Target identity:1%; Query identity:100%] Breast cancer type 1 susceptibility protein Q3YB50 [Target identity:1%; Query identity:100%] Breast and ovarian cancer susceptibility protein Q92897 [Target identity:1%; Query identity:100%] BRCA1; BRCA1 protein Q9NQR3 [Target identity:1%; Query identity:100%] BRCAI; Breast and ovarian cancer susceptibility protein Q9UE29 [Target identity:1%; Query identity:100%] BRCA1 protein	Show » « Hide Candidate cancer biomarkers Mutated genes in cancer Potential transmembrane proteins Phobius predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000151 [ubiquitin ligase complex] GO:0000724 [double-strand break repair via homologous recombination] GO:0000794 [condensed nuclear chromosome] GO:0001726 [ruffle] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0004842 [ubiquitin-protein ligase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005759 [mitochondrial matrix] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006301 [postreplication repair] GO:0006302 [double-strand break repair] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006359 [regulation of transcription from RNA polymerase III promoter] GO:0006633 [fatty acid biosynthetic process] GO:0006915 [apoptotic process] GO:0006974 [response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0007059 [chromosome segregation] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0008274 [gamma-tubulin ring complex] GO:0008630 [DNA damage response, signal transduction resulting in induction of apoptosis] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0010212 [response to ionizing radiation] GO:0015631 [tubulin binding] GO:0016567 [protein ubiquitination] GO:0019899 [enzyme binding] GO:0030521 [androgen receptor signaling pathway] GO:0030529 [ribonucleoprotein complex] GO:0031398 [positive regulation of protein ubiquitination] GO:0031436 [BRCA1-BARD1 complex] GO:0031572 [G2/M transition DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0031941 [filamentous actin] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0035066 [positive regulation of histone acetylation] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0043009 [chordate embryonic development] GO:0043234 [protein complex] GO:0043627 [response to estrogen stimulus] GO:0044212 [transcription regulatory region DNA binding] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0045739 [positive regulation of DNA repair] GO:0045892 [negative regulation of transcription, DNA-dependent] GO:0045893 [positive regulation of transcription, DNA-dependent] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046600 [negative regulation of centriole replication] GO:0050681 [androgen receptor binding] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0051573 [negative regulation of histone H3-K9 methylation] GO:0051865 [protein autoubiquitination] GO:0070512 [positive regulation of histone H4-K20 methylation] GO:0070531 [BRCA1-A complex] GO:0071158 [positive regulation of cell cycle arrest] GO:0071681 [cellular response to indole-3-methanol] GO:0085020 [protein K6-linked ubiquitination] GO:2000145 [regulation of cell motility] GO:2000617 [positive regulation of histone H3-K9 acetylation] GO:2000620 [positive regulation of histone H4-K16 acetylation]	1863	207.7	No
BRCA1-002	ENSP00000420253 ENST00000492859	E9PC22 Show all » « Hide E9PC22 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein Q92897 [Target identity:44%; Query identity:100%] BRCA1; BRCA1 protein G1UI37 [Target identity:38%; Query identity:100%] Breast cancer type 1 susceptibility protein	Show » « Hide Mutated genes in cancer	Show » « Hide GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding]	59	6.7	No
BRCA1-003	ENSP00000418986 ENST00000497488	C9IZW4 Show all » « Hide C9IZW4 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein	Show » « Hide Mutated genes in cancer	Show » « Hide GO:0000794 [condensed nuclear chromosome] GO:0003684 [damaged DNA binding] GO:0005759 [mitochondrial matrix] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0043009 [chordate embryonic development]	177	20	No
BRCA1-004	ENSP00000419988 ENST00000477152	E9PH68 Show all » « Hide E9PH68 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein C9IZW4 [Target identity:28%; Query identity:100%] Breast cancer type 1 susceptibility protein Q4EW25 [Target identity:26%; Query identity:100%] Breast and ovarian cancer suseptibility protein variant E7ENB7 [Target identity:15%; Query identity:100%] Breast cancer type 1 susceptibility protein G4V500 [Target identity:7%; Query identity:100%] Breast cancer associated protein 1 G4V502 [Target identity:7%; Query identity:100%] Breast cancer associated protein 1 G4V503 [Target identity:7%; Query identity:100%] Breast cancer associated protein 1 Q92897 [Target identity:4%; Query identity:100%] BRCA1; BRCA1 protein G1UI37 [Target identity:3%; Query identity:100%] Breast cancer type 1 susceptibility protein	Show » « Hide Mutated genes in cancer	Show » « Hide GO:0000794 [condensed nuclear chromosome] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0005634 [nucleus] GO:0005759 [mitochondrial matrix] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0043009 [chordate embryonic development]	622	70	No
BRCA1-005	ENSP00000418960 ENST00000471181	E9PFC7 Show all » « Hide E9PFC7 [Target identity:100%; Query identity:99%] Breast cancer type 1 susceptibility protein E7EWN5 [Target identity:34%; Query identity:100%] Breast cancer type 1 susceptibility protein Q3B891 [Target identity:25%; Query identity:100%] BRCA1 protein; Breast cancer type 1 susceptibility protein Q7KYU6 [Target identity:12%; Query identity:100%] Breast and ovarian cancer susceptibility protein C9IZW4 [Target identity:9%; Query identity:100%] Breast cancer type 1 susceptibility protein Q4EW25 [Target identity:8%; Query identity:100%] Breast and ovarian cancer suseptibility protein variant E7EN90 [Target identity:3%; Query identity:100%] Breast cancer type 1 susceptibility protein G4V4Z7 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 G4V4Z8 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 G4V500 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 G4V502 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 G4V503 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 Q3YB49 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein Q3YB53 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein C4PFY7 [Target identity:1%; Query identity:100%] BRCA1 G1UI37 [Target identity:1%; Query identity:100%] Breast cancer type 1 susceptibility protein Q3YB50 [Target identity:1%; Query identity:100%] Breast and ovarian cancer susceptibility protein Q92897 [Target identity:1%; Query identity:100%] BRCA1; BRCA1 protein Q9NQR3 [Target identity:1%; Query identity:100%] BRCAI; Breast and ovarian cancer susceptibility protein Q9UE29 [Target identity:1%; Query identity:100%] BRCA1 protein	Show » « Hide Mutated genes in cancer Potential transmembrane proteins Phobius predicted membrane proteins	Show » « Hide GO:0000793 [condensed chromosome] GO:0000794 [condensed nuclear chromosome] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0010033 [response to organic substance] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0043009 [chordate embryonic development]	1884	210.3	No
BRCA1-006	ENSP00000418775 ENST00000493795	E9PFZ0 Show all » « Hide E9PFZ0 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein E7EP70 [Target identity:86%; Query identity:100%] Breast cancer type 1 susceptibility protein; Uncharacterized protein Q7KYU6 [Target identity:12%; Query identity:100%] Breast and ovarian cancer susceptibility protein C9IZW4 [Target identity:9%; Query identity:100%] Breast cancer type 1 susceptibility protein Q4EW25 [Target identity:9%; Query identity:100%] Breast and ovarian cancer suseptibility protein variant G4V4Z7 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 G4V4Z8 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 G4V500 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 G4V502 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 G4V503 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 Q3YB49 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein Q3YB53 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein C4PFY7 [Target identity:1%; Query identity:100%] BRCA1 Q3YB50 [Target identity:1%; Query identity:100%] Breast and ovarian cancer susceptibility protein Q9NQR3 [Target identity:1%; Query identity:100%] BRCAI; Breast and ovarian cancer susceptibility protein Q9UE29 [Target identity:1%; Query identity:100%] BRCA1 protein	Show » « Hide Mutated genes in cancer Potential transmembrane proteins Phobius predicted membrane proteins	Show » « Hide GO:0000794 [condensed nuclear chromosome] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0005634 [nucleus] GO:0005759 [mitochondrial matrix] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0043009 [chordate embryonic development]	1816	202.3	No
BRCA1-007	ENSP00000417148 ENST00000468300	P38398 Show all » « Hide P38398 [Direct mapping] Breast cancer type 1 susceptibility protein E7EN90 [Target identity:9%; Query identity:100%] Breast cancer type 1 susceptibility protein Q9NQR3 [Target identity:4%; Query identity:100%] BRCAI; Breast and ovarian cancer susceptibility protein Q9UE29 [Target identity:4%; Query identity:100%] BRCA1 protein C4PFY7 [Target identity:3%; Query identity:100%] BRCA1 G1UI37 [Target identity:3%; Query identity:100%] Breast cancer type 1 susceptibility protein Q92897 [Target identity:3%; Query identity:100%] BRCA1; BRCA1 protein	Show » « Hide Candidate cancer biomarkers Mutated genes in cancer Potential transmembrane proteins Phobius predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000151 [ubiquitin ligase complex] GO:0000724 [double-strand break repair via homologous recombination] GO:0000794 [condensed nuclear chromosome] GO:0001726 [ruffle] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0004842 [ubiquitin-protein ligase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005759 [mitochondrial matrix] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006301 [postreplication repair] GO:0006302 [double-strand break repair] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006359 [regulation of transcription from RNA polymerase III promoter] GO:0006633 [fatty acid biosynthetic process] GO:0006915 [apoptotic process] GO:0006974 [response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0007059 [chromosome segregation] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0008274 [gamma-tubulin ring complex] GO:0008630 [DNA damage response, signal transduction resulting in induction of apoptosis] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0010212 [response to ionizing radiation] GO:0015631 [tubulin binding] GO:0016567 [protein ubiquitination] GO:0019899 [enzyme binding] GO:0030521 [androgen receptor signaling pathway] GO:0030529 [ribonucleoprotein complex] GO:0031398 [positive regulation of protein ubiquitination] GO:0031436 [BRCA1-BARD1 complex] GO:0031572 [G2/M transition DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0031941 [filamentous actin] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0035066 [positive regulation of histone acetylation] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0043009 [chordate embryonic development] GO:0043234 [protein complex] GO:0043627 [response to estrogen stimulus] GO:0044212 [transcription regulatory region DNA binding] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0045739 [positive regulation of DNA repair] GO:0045892 [negative regulation of transcription, DNA-dependent] GO:0045893 [positive regulation of transcription, DNA-dependent] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046600 [negative regulation of centriole replication] GO:0050681 [androgen receptor binding] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0051573 [negative regulation of histone H3-K9 methylation] GO:0051865 [protein autoubiquitination] GO:0070512 [positive regulation of histone H4-K20 methylation] GO:0070531 [BRCA1-A complex] GO:0071158 [positive regulation of cell cycle arrest] GO:0071681 [cellular response to indole-3-methanol] GO:0085020 [protein K6-linked ubiquitination] GO:2000145 [regulation of cell motility] GO:2000617 [positive regulation of histone H3-K9 acetylation] GO:2000620 [positive regulation of histone H4-K16 acetylation]	699	78.2	No
BRCA1-008	ENSP00000418819 ENST00000493919	B7ZA85 Show all » « Hide B7ZA85 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein; cDNA, FLJ79099, highly similar to Homo sapiens breast cancer 1, early onset (BRCA1), transcript variant BRCA1-delta 11b, mRNA Q9UE29 [Target identity:5%; Query identity:100%] BRCA1 protein C4PFY7 [Target identity:4%; Query identity:100%] BRCA1	Show » « Hide Mutated genes in cancer	Show » « Hide GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding]	572	63.6	No
BRCA1-009	ENSP00000420412 ENST00000478531	E7EUM2 Show all » « Hide E7EUM2 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein E7EQW4 [Target identity:35%; Query identity:100%] Breast cancer type 1 susceptibility protein E7EN90 [Target identity:10%; Query identity:100%] Breast cancer type 1 susceptibility protein Q92897 [Target identity:4%; Query identity:100%] BRCA1; BRCA1 protein Q9UE29 [Target identity:4%; Query identity:100%] BRCA1 protein C4PFY7 [Target identity:3%; Query identity:100%] BRCA1 G1UI37 [Target identity:3%; Query identity:100%] Breast cancer type 1 susceptibility protein	Show » « Hide Mutated genes in cancer	Show » « Hide GO:0000794 [condensed nuclear chromosome] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0005634 [nucleus] GO:0005759 [mitochondrial matrix] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0043009 [chordate embryonic development]	623	69.5	No
BRCA1-010	ENSP00000418548 ENST00000461221	E7EN90 Show all » « Hide E7EN90 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein Q92897 [Target identity:41%; Query identity:100%] BRCA1; BRCA1 protein G1UI37 [Target identity:36%; Query identity:100%] Breast cancer type 1 susceptibility protein	Show » « Hide Mutated genes in cancer	Show » « Hide GO:0000794 [condensed nuclear chromosome] GO:0003684 [damaged DNA binding] GO:0005759 [mitochondrial matrix] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0043009 [chordate embryonic development]	63	7.2	No
BRCA1-011	ENSP00000419274 ENST00000470026	E7EWN5 Show all » « Hide E7EWN5 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein Q3B891 [Target identity:72%; Query identity:100%] BRCA1 protein; Breast cancer type 1 susceptibility protein C9IZW4 [Target identity:27%; Query identity:100%] Breast cancer type 1 susceptibility protein Q4EW25 [Target identity:25%; Query identity:100%] Breast and ovarian cancer suseptibility protein variant E7EN90 [Target identity:9%; Query identity:100%] Breast cancer type 1 susceptibility protein G4V503 [Target identity:7%; Query identity:100%] Breast cancer associated protein 1 G4V500 [Target identity:6%; Query identity:100%] Breast cancer associated protein 1 G4V502 [Target identity:6%; Query identity:100%] Breast cancer associated protein 1 Q92897 [Target identity:4%; Query identity:100%] BRCA1; BRCA1 protein G1UI37 [Target identity:3%; Query identity:100%] Breast cancer type 1 susceptibility protein	Show » « Hide Mutated genes in cancer	Show » « Hide GO:0000794 [condensed nuclear chromosome] GO:0003684 [damaged DNA binding] GO:0005759 [mitochondrial matrix] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0043009 [chordate embryonic development]	649	73.1	No
BRCA1-013	ENSP00000419103 ENST00000494123	Q3B891 Show all » « Hide Q3B891 [Target identity:100%; Query identity:100%] BRCA1 protein; Breast cancer type 1 susceptibility protein C9IZW4 [Target identity:37%; Query identity:100%] Breast cancer type 1 susceptibility protein Q4EW25 [Target identity:35%; Query identity:100%] Breast and ovarian cancer suseptibility protein variant E7EN90 [Target identity:13%; Query identity:100%] Breast cancer type 1 susceptibility protein G4V500 [Target identity:9%; Query identity:100%] Breast cancer associated protein 1 G4V502 [Target identity:9%; Query identity:100%] Breast cancer associated protein 1 G4V503 [Target identity:9%; Query identity:100%] Breast cancer associated protein 1 Q92897 [Target identity:5%; Query identity:100%] BRCA1; BRCA1 protein G1UI37 [Target identity:4%; Query identity:100%] Breast cancer type 1 susceptibility protein	Show » « Hide Mutated genes in cancer	Show » « Hide GO:0000794 [condensed nuclear chromosome] GO:0003684 [damaged DNA binding] GO:0005759 [mitochondrial matrix] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0043009 [chordate embryonic development]	473	53.4	No
BRCA1-014	ENSP00000420705 ENST00000491747	E7ETR2 Show all » « Hide E7ETR2 [Target identity:100%; Query identity:100%] Breast cancer 1, early onset, isoform CRA_d; Breast cancer type 1 susceptibility protein B4DES0 [Target identity:93%; Query identity:100%] cDNA FLJ58524, highly similar to Homo sapiens breast cancer 1, early onset (BRCA1), transcript variant BRCA1-delta 11b, mRNA Q7KYU6 [Target identity:30%; Query identity:100%] Breast and ovarian cancer susceptibility protein E7EN90 [Target identity:8%; Query identity:100%] Breast cancer type 1 susceptibility protein C4PFY7 [Target identity:3%; Query identity:100%] BRCA1 G1UI37 [Target identity:3%; Query identity:100%] Breast cancer type 1 susceptibility protein Q92897 [Target identity:3%; Query identity:100%] BRCA1; BRCA1 protein Q9NQR3 [Target identity:3%; Query identity:100%] BRCAI; Breast and ovarian cancer susceptibility protein Q9UE29 [Target identity:3%; Query identity:100%] BRCA1 protein	Show » « Hide Mutated genes in cancer Potential transmembrane proteins Phobius predicted membrane proteins	Show » « Hide GO:0000794 [condensed nuclear chromosome] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0005634 [nucleus] GO:0005759 [mitochondrial matrix] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0043009 [chordate embryonic development]	759	85	No
BRCA1-015	ENSP00000419481 ENST00000484087	H0Y8B8 Show all » « Hide H0Y8B8 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein Q9UE29 [Target identity:5%; Query identity:100%] BRCA1 protein C4PFY7 [Target identity:4%; Query identity:100%] BRCA1	Show » « Hide Mutated genes in cancer	Show » « Hide GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding]	498	55.5	No
BRCA1-016	ENSP00000420781 ENST00000489037	E7ENB7 Show all » « Hide E7ENB7 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein Q92897 [Target identity:26%; Query identity:100%] BRCA1; BRCA1 protein G1UI37 [Target identity:23%; Query identity:100%] Breast cancer type 1 susceptibility protein	Show » « Hide Mutated genes in cancer	Show » « Hide GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding]	98	11.2	No
BRCA1-017	ENSP00000417554 ENST00000476777	E7EQW4 Show all » « Hide E7EQW4 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein E7EN90 [Target identity:28%; Query identity:100%] Breast cancer type 1 susceptibility protein Q92897 [Target identity:11%; Query identity:100%] BRCA1; BRCA1 protein G1UI37 [Target identity:10%; Query identity:100%] Breast cancer type 1 susceptibility protein	Show » « Hide Mutated genes in cancer	Show » « Hide GO:0000794 [condensed nuclear chromosome] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0005634 [nucleus] GO:0005759 [mitochondrial matrix] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0043009 [chordate embryonic development]	222	25.1	No
BRCA1-018	ENSP00000420201 ENST00000473961	Q4EW25 Show all » « Hide Q4EW25 [Target identity:52%; Query identity:100%] Breast and ovarian cancer suseptibility protein variant G4V500 [Target identity:14%; Query identity:100%] Breast cancer associated protein 1 G4V503 [Target identity:14%; Query identity:100%] Breast cancer associated protein 1 G4V502 [Target identity:13%; Query identity:100%] Breast cancer associated protein 1	Show » « Hide Mutated genes in cancer		319	35.9	No
BRCA1-019	ENSP00000418212 ENST00000487825	H0Y881 Show all » « Hide H0Y881 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein	Show » « Hide Mutated genes in cancer	Show » « Hide GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding]	266	29.5	No
BRCA1-020	ENSP00000417988 ENST00000461798	E7EN90 Show all » « Hide E7EN90 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein Q92897 [Target identity:41%; Query identity:100%] BRCA1; BRCA1 protein G1UI37 [Target identity:36%; Query identity:100%] Breast cancer type 1 susceptibility protein	Show » « Hide Mutated genes in cancer	Show » « Hide GO:0000794 [condensed nuclear chromosome] GO:0003684 [damaged DNA binding] GO:0005759 [mitochondrial matrix] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0043009 [chordate embryonic development]	63	7.2	No
BRCA1-022	ENSP00000417241 ENST00000461574	G4V4Z8 Show all » « Hide G4V4Z8 [Target identity:20%; Query identity:100%] Breast cancer associated protein 1 G4V4Z7 [Target identity:18%; Query identity:100%] Breast cancer associated protein 1	Show » « Hide Mutated genes in cancer		242	26.3	No
BRCA1-023	ENSP00000465818 ENST00000586385	C6YB45 Show all » « Hide C6YB45 [Target identity:100%; Query identity:100%] BRCA1 isoform E1aA-∆2-17 Q9NQR3 [Target identity:16%; Query identity:100%] BRCAI; Breast and ovarian cancer susceptibility protein C4PFY7 [Target identity:13%; Query identity:100%] BRCA1	Show » « Hide Mutated genes in cancer Potential transmembrane proteins Phobius predicted membrane proteins TMHMM predicted membrane proteins		173	19.8	No
BRCA1-024	ENSP00000467329 ENST00000591534	Q7KYU6 Show all » « Hide Q7KYU6 [Target identity:65%; Query identity:100%] Breast and ovarian cancer susceptibility protein Q9UE29 [Target identity:8%; Query identity:100%] BRCA1 protein Q9NQR3 [Target identity:7%; Query identity:100%] BRCAI; Breast and ovarian cancer susceptibility protein C4PFY7 [Target identity:6%; Query identity:100%] BRCA1	Show » « Hide Mutated genes in cancer		354	39.8	No
BRCA1-025	ENSP00000465347 ENST00000591849		Show » « Hide Mutated genes in cancer		96	10.9	No
BRCA1-026	ENSP00000397145 ENST00000412061	P38398 Show all » « Hide P38398 [Direct mapping] Breast cancer type 1 susceptibility protein C9IZW4 [Target identity:40%; Query identity:100%] Breast cancer type 1 susceptibility protein Q4EW25 [Target identity:37%; Query identity:100%] Breast and ovarian cancer suseptibility protein variant G4V500 [Target identity:10%; Query identity:100%] Breast cancer associated protein 1 G4V502 [Target identity:10%; Query identity:100%] Breast cancer associated protein 1 G4V503 [Target identity:10%; Query identity:100%] Breast cancer associated protein 1	Show » « Hide Candidate cancer biomarkers Mutated genes in cancer Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000151 [ubiquitin ligase complex] GO:0000724 [double-strand break repair via homologous recombination] GO:0000794 [condensed nuclear chromosome] GO:0001726 [ruffle] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0004842 [ubiquitin-protein ligase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005759 [mitochondrial matrix] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006301 [postreplication repair] GO:0006302 [double-strand break repair] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006359 [regulation of transcription from RNA polymerase III promoter] GO:0006633 [fatty acid biosynthetic process] GO:0006915 [apoptotic process] GO:0006974 [response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0007059 [chromosome segregation] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0008274 [gamma-tubulin ring complex] GO:0008630 [DNA damage response, signal transduction resulting in induction of apoptosis] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0010212 [response to ionizing radiation] GO:0015631 [tubulin binding] GO:0016567 [protein ubiquitination] GO:0019899 [enzyme binding] GO:0030521 [androgen receptor signaling pathway] GO:0030529 [ribonucleoprotein complex] GO:0031398 [positive regulation of protein ubiquitination] GO:0031436 [BRCA1-BARD1 complex] GO:0031572 [G2/M transition DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0031941 [filamentous actin] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0035066 [positive regulation of histone acetylation] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0043009 [chordate embryonic development] GO:0043234 [protein complex] GO:0043627 [response to estrogen stimulus] GO:0044212 [transcription regulatory region DNA binding] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0045739 [positive regulation of DNA repair] GO:0045892 [negative regulation of transcription, DNA-dependent] GO:0045893 [positive regulation of transcription, DNA-dependent] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046600 [negative regulation of centriole replication] GO:0050681 [androgen receptor binding] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0051573 [negative regulation of histone H3-K9 methylation] GO:0051865 [protein autoubiquitination] GO:0070512 [positive regulation of histone H4-K20 methylation] GO:0070531 [BRCA1-A complex] GO:0071158 [positive regulation of cell cycle arrest] GO:0071681 [cellular response to indole-3-methanol] GO:0085020 [protein K6-linked ubiquitination] GO:2000145 [regulation of cell motility] GO:2000617 [positive regulation of histone H3-K9 acetylation] GO:2000620 [positive regulation of histone H4-K16 acetylation]	437	49	No
BRCA1-201	ENSP00000310938 ENST00000309486	E7EP70 Show all » « Hide E7EP70 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein; Uncharacterized protein Q7KYU6 [Target identity:14%; Query identity:100%] Breast and ovarian cancer susceptibility protein C9IZW4 [Target identity:11%; Query identity:100%] Breast cancer type 1 susceptibility protein G4V4Z8 [Target identity:3%; Query identity:100%] Breast cancer associated protein 1 G4V4Z7 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 Q3YB49 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein Q3YB50 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein Q3YB53 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein C4PFY7 [Target identity:1%; Query identity:100%] BRCA1 Q9NQR3 [Target identity:1%; Query identity:100%] BRCAI; Breast and ovarian cancer susceptibility protein Q9UE29 [Target identity:1%; Query identity:100%] BRCA1 protein	Show » « Hide Mutated genes in cancer Potential transmembrane proteins Phobius predicted membrane proteins	Show » « Hide GO:0000794 [condensed nuclear chromosome] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0005634 [nucleus] GO:0005759 [mitochondrial matrix] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0043009 [chordate embryonic development]	1567	174.4	No
BRCA1-202	ENSP00000246907 ENST00000346315	E7EMP0 Show all » « Hide E7EMP0 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein E7EWN5 [Target identity:39%; Query identity:100%] Breast cancer type 1 susceptibility protein Q3B891 [Target identity:29%; Query identity:100%] BRCA1 protein; Breast cancer type 1 susceptibility protein C9IZW4 [Target identity:10%; Query identity:100%] Breast cancer type 1 susceptibility protein Q4EW25 [Target identity:10%; Query identity:100%] Breast and ovarian cancer suseptibility protein variant E7EN90 [Target identity:3%; Query identity:100%] Breast cancer type 1 susceptibility protein G4V4Z8 [Target identity:3%; Query identity:100%] Breast cancer associated protein 1 G4V4Z7 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 G4V500 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 G4V502 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 G4V503 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 Q3YB49 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein Q3YB50 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein Q3YB53 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein C4PFY7 [Target identity:1%; Query identity:100%] BRCA1 G1UI37 [Target identity:1%; Query identity:100%] Breast cancer type 1 susceptibility protein Q92897 [Target identity:1%; Query identity:100%] BRCA1; BRCA1 protein Q9NQR3 [Target identity:1%; Query identity:100%] BRCAI; Breast and ovarian cancer susceptibility protein	Show » « Hide Mutated genes in cancer Potential transmembrane proteins Phobius predicted membrane proteins	Show » « Hide GO:0000794 [condensed nuclear chromosome] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0005634 [nucleus] GO:0005759 [mitochondrial matrix] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0043009 [chordate embryonic development]	1624	181.4	No
BRCA1-203	ENSP00000338007 ENST00000351666	G3XAC3 Show all » « Hide G3XAC3 [Target identity:100%; Query identity:100%] Breast cancer 1, early onset, isoform CRA_l; Breast cancer type 1 susceptibility protein Q7KYU6 [Target identity:34%; Query identity:100%] Breast and ovarian cancer susceptibility protein E7EN90 [Target identity:9%; Query identity:100%] Breast cancer type 1 susceptibility protein Q9NQR3 [Target identity:4%; Query identity:100%] BRCAI; Breast and ovarian cancer susceptibility protein Q9UE29 [Target identity:4%; Query identity:100%] BRCA1 protein C4PFY7 [Target identity:3%; Query identity:100%] BRCA1 G1UI37 [Target identity:3%; Query identity:100%] Breast cancer type 1 susceptibility protein Q92897 [Target identity:3%; Query identity:100%] BRCA1; BRCA1 protein	Show » « Hide Mutated genes in cancer Potential transmembrane proteins Phobius predicted membrane proteins	Show » « Hide GO:0000794 [condensed nuclear chromosome] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0005634 [nucleus] GO:0005759 [mitochondrial matrix] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0043009 [chordate embryonic development]	680	76.2	No
BRCA1-204	ENSP00000312236 ENST00000352993	P38398 Show all » « Hide P38398 [Direct mapping] Breast cancer type 1 susceptibility protein Q7KYU6 [Target identity:32%; Query identity:100%] Breast and ovarian cancer susceptibility protein E7EN90 [Target identity:8%; Query identity:100%] Breast cancer type 1 susceptibility protein Q9UE29 [Target identity:4%; Query identity:100%] BRCA1 protein C4PFY7 [Target identity:3%; Query identity:100%] BRCA1 G1UI37 [Target identity:3%; Query identity:100%] Breast cancer type 1 susceptibility protein Q92897 [Target identity:3%; Query identity:100%] BRCA1; BRCA1 protein Q9NQR3 [Target identity:3%; Query identity:100%] BRCAI; Breast and ovarian cancer susceptibility protein	Show » « Hide Candidate cancer biomarkers Mutated genes in cancer Potential transmembrane proteins Phobius predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000151 [ubiquitin ligase complex] GO:0000724 [double-strand break repair via homologous recombination] GO:0000794 [condensed nuclear chromosome] GO:0001726 [ruffle] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0004842 [ubiquitin-protein ligase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005759 [mitochondrial matrix] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006301 [postreplication repair] GO:0006302 [double-strand break repair] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006359 [regulation of transcription from RNA polymerase III promoter] GO:0006633 [fatty acid biosynthetic process] GO:0006915 [apoptotic process] GO:0006974 [response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0007059 [chromosome segregation] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0008274 [gamma-tubulin ring complex] GO:0008630 [DNA damage response, signal transduction resulting in induction of apoptosis] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0010212 [response to ionizing radiation] GO:0015631 [tubulin binding] GO:0016567 [protein ubiquitination] GO:0019899 [enzyme binding] GO:0030521 [androgen receptor signaling pathway] GO:0030529 [ribonucleoprotein complex] GO:0031398 [positive regulation of protein ubiquitination] GO:0031436 [BRCA1-BARD1 complex] GO:0031572 [G2/M transition DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0031941 [filamentous actin] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0035066 [positive regulation of histone acetylation] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0043009 [chordate embryonic development] GO:0043234 [protein complex] GO:0043627 [response to estrogen stimulus] GO:0044212 [transcription regulatory region DNA binding] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0045739 [positive regulation of DNA repair] GO:0045892 [negative regulation of transcription, DNA-dependent] GO:0045893 [positive regulation of transcription, DNA-dependent] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046600 [negative regulation of centriole replication] GO:0050681 [androgen receptor binding] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0051573 [negative regulation of histone H3-K9 methylation] GO:0051865 [protein autoubiquitination] GO:0070512 [positive regulation of histone H4-K20 methylation] GO:0070531 [BRCA1-A complex] GO:0071158 [positive regulation of cell cycle arrest] GO:0071681 [cellular response to indole-3-methanol] GO:0085020 [protein K6-linked ubiquitination] GO:2000145 [regulation of cell motility] GO:2000617 [positive regulation of histone H3-K9 acetylation] GO:2000620 [positive regulation of histone H4-K16 acetylation]	721	80.6	No
BRCA1-205	ENSP00000326002 ENST00000354071	F8W8H7 Show all » « Hide F8W8H7 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein E7EWN5 [Target identity:40%; Query identity:100%] Breast cancer type 1 susceptibility protein Q3B891 [Target identity:29%; Query identity:100%] BRCA1 protein; Breast cancer type 1 susceptibility protein C9IZW4 [Target identity:11%; Query identity:100%] Breast cancer type 1 susceptibility protein Q4EW25 [Target identity:10%; Query identity:100%] Breast and ovarian cancer suseptibility protein variant E7EN90 [Target identity:3%; Query identity:100%] Breast cancer type 1 susceptibility protein G4V4Z8 [Target identity:3%; Query identity:100%] Breast cancer associated protein 1 G4V4Z7 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 G4V500 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 G4V502 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 G4V503 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 Q3YB49 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein Q3YB50 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein Q3YB53 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein G1UI37 [Target identity:1%; Query identity:100%] Breast cancer type 1 susceptibility protein Q92897 [Target identity:1%; Query identity:100%] BRCA1; BRCA1 protein Q9NQR3 [Target identity:1%; Query identity:100%] BRCAI; Breast and ovarian cancer susceptibility protein	Show » « Hide Mutated genes in cancer	Show » « Hide GO:0000794 [condensed nuclear chromosome] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0005634 [nucleus] GO:0005759 [mitochondrial matrix] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0043009 [chordate embryonic development]	1598	178.3	No
BRCA1-206	ENSP00000377294 ENST00000393691	P38398 Show all » « Hide P38398 [Direct mapping] Breast cancer type 1 susceptibility protein B4DES0 [Target identity:100%; Query identity:100%] cDNA FLJ58524, highly similar to Homo sapiens breast cancer 1, early onset (BRCA1), transcript variant BRCA1-delta 11b, mRNA Q7KYU6 [Target identity:32%; Query identity:100%] Breast and ovarian cancer susceptibility protein Q9UE29 [Target identity:4%; Query identity:100%] BRCA1 protein C4PFY7 [Target identity:3%; Query identity:100%] BRCA1 Q9NQR3 [Target identity:3%; Query identity:100%] BRCAI; Breast and ovarian cancer susceptibility protein	Show » « Hide Candidate cancer biomarkers Mutated genes in cancer Potential transmembrane proteins Phobius predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000151 [ubiquitin ligase complex] GO:0000724 [double-strand break repair via homologous recombination] GO:0000794 [condensed nuclear chromosome] GO:0001726 [ruffle] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0004842 [ubiquitin-protein ligase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005759 [mitochondrial matrix] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006301 [postreplication repair] GO:0006302 [double-strand break repair] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006359 [regulation of transcription from RNA polymerase III promoter] GO:0006633 [fatty acid biosynthetic process] GO:0006915 [apoptotic process] GO:0006974 [response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0007059 [chromosome segregation] GO:0007098 [centrosome cycle] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008270 [zinc ion binding] GO:0008274 [gamma-tubulin ring complex] GO:0008630 [DNA damage response, signal transduction resulting in induction of apoptosis] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0010212 [response to ionizing radiation] GO:0015631 [tubulin binding] GO:0016567 [protein ubiquitination] GO:0019899 [enzyme binding] GO:0030521 [androgen receptor signaling pathway] GO:0030529 [ribonucleoprotein complex] GO:0031398 [positive regulation of protein ubiquitination] GO:0031436 [BRCA1-BARD1 complex] GO:0031572 [G2/M transition DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0031941 [filamentous actin] GO:0032355 [response to estradiol stimulus] GO:0033993 [response to lipid] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0035066 [positive regulation of histone acetylation] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0043009 [chordate embryonic development] GO:0043234 [protein complex] GO:0043627 [response to estrogen stimulus] GO:0044212 [transcription regulatory region DNA binding] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0045739 [positive regulation of DNA repair] GO:0045892 [negative regulation of transcription, DNA-dependent] GO:0045893 [positive regulation of transcription, DNA-dependent] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046600 [negative regulation of centriole replication] GO:0050681 [androgen receptor binding] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0051573 [negative regulation of histone H3-K9 methylation] GO:0051865 [protein autoubiquitination] GO:0070512 [positive regulation of histone H4-K20 methylation] GO:0070531 [BRCA1-A complex] GO:0071158 [positive regulation of cell cycle arrest] GO:0071681 [cellular response to indole-3-methanol] GO:0085020 [protein K6-linked ubiquitination] GO:2000145 [regulation of cell motility] GO:2000617 [positive regulation of histone H3-K9 acetylation] GO:2000620 [positive regulation of histone H4-K16 acetylation]	712	79.6	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.