ALOX5

GENE INFORMATION

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Gene name

ALOX5 (HGNC Symbol)

Synonyms

5-LOX

Description

arachidonate 5-lipoxygenase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

10 (Chromosome progress)

Cytoband

q11.21

Chromosome location (bp)

45869661 - 45941561

Ensembl

ENSG00000012779 (version 73.37)

Entrez gene

240

UniProt

P09917 (UniProt - Evidence at protein level)

neXtProt

NX_P09917

Antibodypedia

ALOX5 antibodies
 

PROTEIN VIEW

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ALOX5-001
 
ALOX5-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ALOX5-001 ENSP00000363512
ENST00000374391
P09917
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Show » Show » 674 78 No 0
ALOX5-201 ENSP00000437634
ENST00000542434
P09917
Show all »
Show » Show » 617 71.6 No 0