MAP4K5

GENE INFORMATION

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Gene name

MAP4K5 (HGNC Symbol)

Synonyms

GCKR, KHS, KHS1

Description

mitogen-activated protein kinase kinase kinase kinase 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

14 (Chromosome progress)

Cytoband

q21.3

Chromosome location (bp)

50885219 - 51027844

Ensembl

ENSG00000012983 (version 73.37)

Entrez gene

11183

UniProt

Q9Y4K4 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y4K4

Antibodypedia

MAP4K5 antibodies
 

PROTEIN VIEW

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MAP4K5-001
 
MAP4K5-004
 
MAP4K5-006
 
MAP4K5-008
 
MAP4K5-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP4K5-001 ENSP00000013125
ENST00000013125
Q9Y4K4
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Show » Show » 846 95 No 0
MAP4K5-004 ENSP00000451452
ENST00000554273
G3V3V7
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Show » 56 6.2 No 0
MAP4K5-006 ENSP00000451980
ENST00000557390
G3V4T8
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Show » 137 15.5 No 0
MAP4K5-008 ENSP00000452289
ENST00000555216
G3V5C6
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Show » 108 12.1 No 0
MAP4K5-011 ENSP00000451926
ENST00000554091
G3V4Q4
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Show » 62 6.9 No 0