COX15

GENE INFORMATION

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Gene name

COX15

Synonyms

Description

cytochrome c oxidase assembly homolog 15 (yeast) (HGNC Symbol)

Entrez gene summary

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region. [provided by RefSeq, Jul 2008]

Chromosome

10 (Chromosome progress)

Cytoband

q24.2

Chromosome location (bp)

101471601 - 101491857

Ensembl

ENSG00000014919 (version 73.37)

Entrez gene

1355

UniProt

Q7KZN9 (UniProt - Evidence at protein level)

neXtProt

NX_Q7KZN9

Antibodypedia

COX15 antibodies
 

PROTEIN VIEW

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COX15-001
 
COX15-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

COX15-001 ENSP00000016171
ENST00000016171
Q7KZN9
Show all »
Show » Show » 410 46 No 8
COX15-002 ENSP00000359514
ENST00000370483
Q7KZN9
Show all »
Show » Show » 388 43.8 No 7