SLC11A1

GENERAL INFORMATION

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Gene name

SLC11A1

Gene description

Solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1

Protein class

Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (lung)
GTEx:Group enriched (lung, spleen)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression at variable levels in several tissues, including subsets of immune cells in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Data reliability

Uncertain based on 1 antibody.
HPA029590
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (lung)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (lung, spleen)

Organ

Expression



GENE INFORMATION

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Gene name

SLC11A1 (HGNC Symbol)

Synonyms

LSH, NRAMP, NRAMP1

Description

Solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 (HGNC Symbol)

Entrez gene summary

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q35

Chromosome location (bp)

218382029 - 218396894

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000018280 (version 78.38)

Entrez gene

6556

UniProt

P49279 (UniProt - Evidence at transcript level)

neXtProt

NX_P49279

Antibodypedia

SLC11A1 antibodies


PROTEIN BROWSER

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ENST00000233202
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC11A1-001 ENSP00000233202
ENST00000233202
P49279
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