SLC11A1

GENE INFORMATION

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Gene name

SLC11A1 (HGNC Symbol)

Synonyms

LSH, NRAMP, NRAMP1

Description

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 (HGNC Symbol)

Entrez gene summary

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

q35

Chromosome location (bp)

219246752 - 219261617

Ensembl

ENSG00000018280 (version 73.37)

Entrez gene

6556

UniProt

P49279 (UniProt - Evidence at transcript level)

neXtProt

NX_P49279

Antibodypedia

SLC11A1 antibodies
 

PROTEIN VIEW

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SLC11A1-001
 
SLC11A1-003
 
SLC11A1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC11A1-001 ENSP00000233202
ENST00000233202
P49279
Show all »
Show » Show » 550 59.9 No >9
SLC11A1-003 ENSP00000346320
ENST00000354352
Q9HBK0
Show all »
Show » Show » 163 17.3 No 2
SLC11A1-201 ENSP00000443435
ENST00000539932
C0H5Y3
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Show » Show » 432 47.3 No >9