ATP1A2

GENE INFORMATION

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Gene name

ATP1A2 (HGNC Symbol)

Synonyms

FHM2, MHP2

Description

ATPase, Na+/K+ transporting, alpha 2 polypeptide (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008]

Chromosome

1 (Chromosome progress)

Cytoband

q23.2

Chromosome location (bp)

160085549 - 160113381

Ensembl

ENSG00000018625 (version 73.37)

Entrez gene

477

UniProt

P50993 (UniProt - Evidence at protein level)

neXtProt

NX_P50993

Antibodypedia

ATP1A2 antibodies
 

PROTEIN VIEW

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ATP1A2-001
 
ATP1A2-003
 
ATP1A2-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP1A2-001 ENSP00000354490
ENST00000361216
P50993
Show all »
Show » Show » 1020 112.3 No >9
ATP1A2-003 ENSP00000376066
ENST00000392233
B1AKY9
Show all »
Show » Show » 1009 110.9 No >9
ATP1A2-008 ENSP00000411705
ENST00000447527
Show » Show » 714 78.8 No 8