PHLDB1

GENE INFORMATION

? »

Gene name

PHLDB1 (HGNC Symbol)

Synonyms

FLJ00141, KIAA0638, LL5a

Description

Pleckstrin homology-like domain, family B, member 1 (HGNC Symbol)

Entrez gene summary

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Chromosome

11

Cytoband

q23.3

Chromosome location (bp)

118477155 - 118528741

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000019144 (version 75.37)

Entrez gene

102466719

UniProt

Q86UU1 (UniProt - Evidence at protein level)

neXtProt

NX_Q86UU1

Antibodypedia

PHLDB1 antibodies
 

PROTEIN VIEW

? »
 
 
 
PHLDB1-001
 
PHLDB1-002
 
PHLDB1-003
 
PHLDB1-019
 
PHLDB1-020
 
PHLDB1-036
 
PHLDB1-038
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PHLDB1-001 ENSP00000354498
ENST00000361417
Q86UU1
Show all »
Show » Show » 1377 151.2 No 0
PHLDB1-002 ENSP00000431508
ENST00000530994
Q86UU1
Show all »
Show » Show » 995 107.4 No 0
PHLDB1-003 ENSP00000435520
ENST00000528594
Q86UU1
Show all »
Show » Show » 995 107.4 No 0
PHLDB1-019 ENSP00000432059
ENST00000525698
H0YCP1
Show all »
Show » 99 11.2 No 0
PHLDB1-020 ENSP00000348359
ENST00000356063
Q86UU1
Show all »
Show » Show » 1319 144.7 No 0
PHLDB1-036 ENSP00000435388
ENST00000527898
E9PKC1
Show all »
Show » 417 46.9 No 0
PHLDB1-038 ENSP00000434905
ENST00000524713
E9PMZ5
Show all »
Show » 509 56.7 No 0