CYP24A1

GENE INFORMATION

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Gene name

CYP24A1 (HGNC Symbol)

Synonyms

CP24, CYP24, P450-CC24

Description

cytochrome P450, family 24, subfamily A, polypeptide 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

20 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

52769988 - 52790512

Ensembl

ENSG00000019186 (version 73.37)

Entrez gene

1591

UniProt

Q07973 (UniProt - Evidence at protein level)

neXtProt

NX_Q07973

Antibodypedia

CYP24A1 antibodies
 

PROTEIN VIEW

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CYP24A1-003
 
CYP24A1-004
 
CYP24A1-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP24A1-003 ENSP00000216862
ENST00000216862
Q07973
Show all »
Show » Show » 514 58.9 No 0
CYP24A1-004 ENSP00000379285
ENST00000395955
Q07973
Show all »
Show » Show » 448 51.2 No 0
CYP24A1-006 ENSP00000379284
ENST00000395954
Q5I2W7
Show all »
Show » Show » 372 43.1 No 0