The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Renal tubules and megakaryocytes in bone marrow displayed strong cytoplasmic immunoreactivity while the intestine, trophoblasts and cilia in e.g. respiratory epithelium and fallopian tubes showed distinct membranous staining. Moderate staining was observed in hepatocytes, decidual cells and smooth muscle. Remaining normal tissues showed weak cytoplasmic positivity or were negative.
Strong cytoplasmic and nuclear positivity was observed in cerebellum, glandular cells in female genitalia and subsets of cells in seminiferous ducts, decidua, exocrine pancreas and neurons. Remaining normal tissues were negative.
Most of the normal tissues displayed moderate cytoplasmic positivity and additional nuclear staining in a few cases. Seminiferous duct cells showed distinct nuclear positivity and thyroid gland displayed strong cytoplasmic staining. The liver, pancreas, glial cells and lymphoid cells were weakly stained or negative.