RUNX3

GENE INFORMATION

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Gene name

RUNX3 (HGNC Symbol)

Synonyms

AML2, CBFA3, PEBP2A3

Description

runt-related transcription factor 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p36.11

Chromosome location (bp)

25226002 - 25291612

Ensembl

ENSG00000020633 (version 73.37)

Entrez gene

864

UniProt

Q13761 (UniProt - Evidence at protein level)

neXtProt

NX_Q13761

Antibodypedia

RUNX3 antibodies
 

PROTEIN VIEW

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RUNX3-001
 
RUNX3-002
 
RUNX3-201
 
RUNX3-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RUNX3-001 ENSP00000308051
ENST00000308873
Q13761
Show all »
Show » Show » 415 44.4 No 0
RUNX3-002 ENSP00000343477
ENST00000338888
Q13761
Show all »
Show » Show » 429 45.9 No 0
RUNX3-201 ENSP00000382800
ENST00000399916
Q13761
Show all »
Show » Show » 429 45.9 No 0
RUNX3-202 ENSP00000444872
ENST00000540420
F5H4J4
Show all »
Show » 322 34.7 No 0