The Human Protein Atlas

GENE INFORMATION

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Gene name	FHL1 (HGNC Symbol)
Synonyms	bA535K18.1, FHL1B, FLH1A, KYO-T, MGC111107, SLIM1, XMPMA
Description	four and a half LIM domains 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]
Chromosome	X (Chromosome progress)
Cytoband	q26.3
Chromosome location (bp)	135229559 - 135293518
Ensembl	ENSG00000022267 (version 69.37)
Entrez gene	2273
UniProt	Q13642
neXtProt	NX_Q13642
Antibodypedia	FHL1 antibodies

PROTEIN VIEW

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FHL1-001		FHL1-002		FHL1-003		FHL1-004		FHL1-006		FHL1-007		FHL1-008		FHL1-010		FHL1-011		FHL1-012		FHL1-013		FHL1-201		FHL1-202		FHL1-203		FHL1-204		FHL1-205

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
FHL1-001	ENSP00000359724 ENST00000370690	Q13642 Show all » « Hide Q13642 [Direct mapping] Four and a half LIM domains protein 1 Q5JXI8 [Target identity:91%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH7 [Target identity:73%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI3 [Target identity:73%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH8 [Target identity:72%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH9 [Target identity:55%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI0 [Target identity:50%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1	Show » « Hide Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007517 [muscle organ development] GO:0008270 [zinc ion binding] GO:0009887 [organ morphogenesis] GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle] GO:0030154 [cell differentiation] GO:0030308 [negative regulation of cell growth] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]	280	31.9	No	0
FHL1-002	ENSP00000071281 ENST00000345434	Q13642 Show all » « Hide Q13642 [Direct mapping] Four and a half LIM domains protein 1 Q5JXI3 [Target identity:64%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH7 [Target identity:63%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH8 [Target identity:63%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH9 [Target identity:47%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI0 [Target identity:43%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1	Show » « Hide Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007517 [muscle organ development] GO:0008270 [zinc ion binding] GO:0009887 [organ morphogenesis] GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle] GO:0030154 [cell differentiation] GO:0030308 [negative regulation of cell growth] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]	323	36.3	No	0
FHL1-003	ENSP00000359710 ENST00000370676	Q5JXI2 Show all » « Hide Q5JXI2 [Target identity:100%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH9 [Target identity:73%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI0 [Target identity:67%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1		Show » « Hide GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008270 [zinc ion binding]	210	23.7	No	0
FHL1-004	ENSP00000359717 ENST00000370683	Q13642 Show all » « Hide Q13642 [Direct mapping] Four and a half LIM domains protein 1 B7Z5V0 [Target identity:92%; Query identity:100%] Four and a half LIM domains protein 1; cDNA FLJ53647, highly similar to Four and a half LIM domains protein 1 Q5JXI8 [Target identity:86%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH7 [Target identity:69%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI3 [Target identity:69%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH8 [Target identity:68%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH9 [Target identity:52%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI0 [Target identity:47%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1	Show » « Hide Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007517 [muscle organ development] GO:0008270 [zinc ion binding] GO:0009887 [organ morphogenesis] GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle] GO:0030154 [cell differentiation] GO:0030308 [negative regulation of cell growth] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]	296	33.6	No	0
FHL1-006	ENSP00000391779 ENST00000420362	Q5JXH8 Show all » « Hide Q5JXH8 [Target identity:100%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH9 [Target identity:75%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI0 [Target identity:69%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1		Show » « Hide GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008270 [zinc ion binding]	204	23.2	No	0
FHL1-007	ENSP00000359708 ENST00000370674	Q5JXI8 Show all » « Hide Q5JXI8 [Target identity:100%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI3 [Target identity:80%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH7 [Target identity:79%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH8 [Target identity:79%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH9 [Target identity:60%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI0 [Target identity:54%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1		Show » « Hide GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008270 [zinc ion binding]	257	29.2	No	0
FHL1-008	ENSP00000408038 ENST00000452016	Q5JXI3 Show all » « Hide Q5JXI3 [Target identity:100%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH7 [Target identity:99%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH8 [Target identity:98%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH9 [Target identity:74%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI0 [Target identity:68%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1		Show » « Hide GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008270 [zinc ion binding]	207	23.6	No	0
FHL1-010	ENSP00000413798 ENST00000434885	Q5JXI3 Show all » « Hide Q5JXI3 [Target identity:100%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH7 [Target identity:99%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH8 [Target identity:98%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH9 [Target identity:74%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI0 [Target identity:68%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1		Show » « Hide GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008270 [zinc ion binding]	207	23.6	No	0
FHL1-011	ENSP00000389920 ENST00000458357	Q5JXH9 Show all » « Hide Q5JXH9 [Target identity:100%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI0 [Target identity:90%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1		Show » « Hide GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008270 [zinc ion binding]	155	17.8	No	0
FHL1-012	ENSP00000412642 ENST00000456445	Q5JXH7 Show all » « Hide Q5JXH7 [Target identity:100%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH8 [Target identity:99%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH9 [Target identity:75%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI0 [Target identity:68%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1		Show » « Hide GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008270 [zinc ion binding]	205	23.3	No	0
FHL1-013	ENSP00000414604 ENST00000449474	Q5JXI0 Show all » « Hide Q5JXI0 [Target identity:100%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1		Show » « Hide GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008270 [zinc ion binding]	141	16.2	No	0
FHL1-201	ENSP00000377709 ENST00000394153	Q13642 Show all » « Hide Q13642 [Direct mapping] Four and a half LIM domains protein 1 Q5JXI8 [Target identity:91%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH7 [Target identity:73%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI3 [Target identity:73%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH8 [Target identity:72%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH9 [Target identity:55%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI0 [Target identity:50%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1	Show » « Hide Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007517 [muscle organ development] GO:0008270 [zinc ion binding] GO:0009887 [organ morphogenesis] GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle] GO:0030154 [cell differentiation] GO:0030308 [negative regulation of cell growth] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]	280	31.9	No	0
FHL1-202	ENSP00000377710 ENST00000394155	Q13642 Show all » « Hide Q13642 [Direct mapping] Four and a half LIM domains protein 1 Q5JXI3 [Target identity:64%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH7 [Target identity:63%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH8 [Target identity:63%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH9 [Target identity:47%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI0 [Target identity:43%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1	Show » « Hide Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007517 [muscle organ development] GO:0008270 [zinc ion binding] GO:0009887 [organ morphogenesis] GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle] GO:0030154 [cell differentiation] GO:0030308 [negative regulation of cell growth] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]	323	36.3	No	0
FHL1-203	ENSP00000444815 ENST00000535737	Q13642 Show all » « Hide Q13642 [Direct mapping] Four and a half LIM domains protein 1 Q5JXI8 [Target identity:91%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH7 [Target identity:73%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI3 [Target identity:73%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH8 [Target identity:72%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH9 [Target identity:55%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI0 [Target identity:50%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1	Show » « Hide Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007517 [muscle organ development] GO:0008270 [zinc ion binding] GO:0009887 [organ morphogenesis] GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle] GO:0030154 [cell differentiation] GO:0030308 [negative regulation of cell growth] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]	280	31.9	No	0
FHL1-204	ENSP00000437673 ENST00000539015	Q13642 Show all » « Hide Q13642 [Direct mapping] Four and a half LIM domains protein 1 Q5JXI8 [Target identity:83%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH7 [Target identity:66%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH8 [Target identity:66%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI3 [Target identity:66%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH9 [Target identity:50%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI0 [Target identity:45%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1	Show » « Hide Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007517 [muscle organ development] GO:0008270 [zinc ion binding] GO:0009887 [organ morphogenesis] GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle] GO:0030154 [cell differentiation] GO:0030308 [negative regulation of cell growth] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]	309	35	Yes	0
FHL1-205	ENSP00000443333 ENST00000543669	Q13642 Show all » « Hide Q13642 [Direct mapping] Four and a half LIM domains protein 1 Q5JXI8 [Target identity:91%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH7 [Target identity:73%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI3 [Target identity:73%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH8 [Target identity:72%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXH9 [Target identity:55%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1 Q5JXI0 [Target identity:50%; Query identity:100%] Four and a half LIM domains 1; Four and a half LIM domains protein 1	Show » « Hide Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007517 [muscle organ development] GO:0008270 [zinc ion binding] GO:0009887 [organ morphogenesis] GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle] GO:0030154 [cell differentiation] GO:0030308 [negative regulation of cell growth] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]	280	31.9	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.