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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
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Gene name |
NDUFS1 (HGNC Symbol) |
Synonyms |
CI-75k |
Description |
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) (HGNC Symbol) |
Entrez gene summary |
The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] |
Chromosome |
2 (Chromosome progress)
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Cytoband |
q33.3 |
Chromosome location (bp) |
206986149 - 207024327 |
Ensembl |
ENSG00000023228 (version 69.37) |
Entrez gene |
4719 |
UniProt |
P28331 |
neXtProt |
NX_P28331 |
Antibodypedia |
NDUFS1 antibodies |
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed ( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
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| NDUFS1-001 |
ENSP00000233190
ENST00000233190
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P28331 Show all »
« Hide
P28331 [Direct mapping]NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial E5KRK5 [Target identity:100%; Query identity:100%]Mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit; NADH dehydrogenase (Ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase), isoform CRA_b B4DJ81 [Target identity:84%; Query identity:100%]NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; cDNA FLJ60586, highly similar to NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Q9P1A0 [Target identity:35%; Query identity:100%]NDUFS1 protein; PRO1304 C9JPQ5 [Target identity:17%; Query identity:100%]NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
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Show »
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Enzymes Oxidoreductases Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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Show »
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727 |
79.5 |
No |
0 |
| NDUFS1-002 |
ENSP00000409689
ENST00000432169
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P28331 Show all »
« Hide
P28331 [Direct mapping]NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial B4DJ81 [Target identity:99%; Query identity:100%]NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; cDNA FLJ60586, highly similar to NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Q9P1A0 [Target identity:41%; Query identity:100%]NDUFS1 protein; PRO1304
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Show »
« Hide
Enzymes Oxidoreductases Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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Show »
« Hide
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616 |
67.5 |
No |
0 |
| NDUFS1-003 |
ENSP00000409766
ENST00000440274
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E7ENF3 Show all »
« Hide
E7ENF3 [Target identity:100%; Query identity:100%]NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial B4DJ81 [Target identity:88%; Query identity:100%]NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; cDNA FLJ60586, highly similar to NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Q9P1A0 [Target identity:36%; Query identity:100%]NDUFS1 protein; PRO1304
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Show »
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691 |
75.4 |
No |
0 |
| NDUFS1-004 |
ENSP00000400976
ENST00000457011
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B4DJ81 Show all »
« Hide
B4DJ81 [Target identity:100%; Query identity:100%]NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; cDNA FLJ60586, highly similar to NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Q9P1A0 [Target identity:41%; Query identity:100%]NDUFS1 protein; PRO1304
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Show »
« Hide
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611 |
66.9 |
No |
0 |
| NDUFS1-005 |
ENSP00000397760
ENST00000423725
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P28331 Show all »
« Hide
P28331 [Direct mapping]NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial B4DJ81 [Target identity:91%; Query identity:100%]NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; cDNA FLJ60586, highly similar to NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Q9P1A0 [Target identity:38%; Query identity:100%]NDUFS1 protein; PRO1304
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Show »
« Hide
Enzymes Oxidoreductases Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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Show »
« Hide
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670 |
73.5 |
No |
0 |
| NDUFS1-007 |
ENSP00000399912
ENST00000449699
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P28331 Show all »
« Hide
P28331 [Direct mapping]NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial E5KRK5 [Target identity:100%; Query identity:100%]Mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit; NADH dehydrogenase (Ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase), isoform CRA_b B4DJ81 [Target identity:84%; Query identity:100%]NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; cDNA FLJ60586, highly similar to NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Q9P1A0 [Target identity:35%; Query identity:100%]NDUFS1 protein; PRO1304 C9JPQ5 [Target identity:17%; Query identity:100%]NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
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Show »
« Hide
Enzymes Oxidoreductases Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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Show »
« Hide
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727 |
79.5 |
No |
0 |
| NDUFS1-008 |
ENSP00000389413
ENST00000454195
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C9JPQ5 Show all »
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C9JPQ5 [Target identity:100%; Query identity:100%]NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
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Show »
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130 |
14.2 |
No |
0 |
| NDUFS1-009 |
ENSP00000395553
ENST00000456284
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F8WDL5 Show all »
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F8WDL5 [Target identity:100%; Query identity:100%]NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
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Show »
« Hide
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91 |
9.9 |
No |
0 |
| NDUFS1-201 |
ENSP00000392709
ENST00000455934
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P28331 Show all »
« Hide
P28331 [Direct mapping]NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial E5KRK5 [Target identity:98%; Query identity:100%]Mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit; NADH dehydrogenase (Ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase), isoform CRA_b B4DJ81 [Target identity:82%; Query identity:100%]NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; cDNA FLJ60586, highly similar to NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Q9P1A0 [Target identity:34%; Query identity:100%]NDUFS1 protein; PRO1304 C9JPQ5 [Target identity:17%; Query identity:100%]NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
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Show »
« Hide
Enzymes Oxidoreductases Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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Show »
« Hide
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741 |
81 |
No |
0 |
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