NDUFS1

GENE INFORMATION

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Gene name

NDUFS1 (HGNC Symbol)

Synonyms

CI-75k

Description

NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Chromosome

2 (Chromosome progress)

Cytoband

q33.3

Chromosome location (bp)

206986149 - 207024327

Ensembl

ENSG00000023228 (version 73.37)

Entrez gene

4719

UniProt

P28331 (UniProt - Evidence at protein level)

neXtProt

NX_P28331

Antibodypedia

NDUFS1 antibodies
 

PROTEIN VIEW

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NDUFS1-001
 
NDUFS1-002
 
NDUFS1-003
 
NDUFS1-004
 
NDUFS1-005
 
NDUFS1-007
 
NDUFS1-008
 
NDUFS1-009
 
NDUFS1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NDUFS1-001 ENSP00000233190
ENST00000233190
P28331
Show all »
Show » Show » 727 79.5 No 0
NDUFS1-002 ENSP00000409689
ENST00000432169
P28331
Show all »
Show » Show » 616 67.5 No 0
NDUFS1-003 ENSP00000409766
ENST00000440274
P28331
Show all »
Show » Show » 691 75.4 No 0
NDUFS1-004 ENSP00000400976
ENST00000457011
B4DJ81
Show all »
Show » 611 66.9 No 0
NDUFS1-005 ENSP00000397760
ENST00000423725
P28331
Show all »
Show » Show » 670 73.5 No 0
NDUFS1-007 ENSP00000399912
ENST00000449699
P28331
Show all »
Show » Show » 727 79.5 No 0
NDUFS1-008 ENSP00000389413
ENST00000454195
C9JPQ5
Show all »
Show » 130 14.2 No 0
NDUFS1-009 ENSP00000395553
ENST00000456284
F8WDL5
Show all »
Show » 91 9.9 No 0
NDUFS1-201 ENSP00000392709
ENST00000455934
P28331
Show all »
Show » Show » 741 81 No 0