BIRC3

GENE INFORMATION

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Gene name

BIRC3 (HGNC Symbol)

Synonyms

API2, c-IAP2, cIAP2, hiap-1, MALT2, MIHC, RNF49

Description

baculoviral IAP repeat containing 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]

Chromosome

11 (Chromosome progress)

Cytoband

q22.2

Chromosome location (bp)

102188215 - 102210134

Ensembl

ENSG00000023445 (version 73.37)

Entrez gene

330

UniProt

Q13489 (UniProt - Evidence at protein level)

neXtProt

NX_Q13489

Antibodypedia

BIRC3 antibodies
 

PROTEIN VIEW

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BIRC3-001
 
BIRC3-002
 
BIRC3-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BIRC3-001 ENSP00000432907
ENST00000532808
Q13489
Show all »
Show » Show » 604 68.4 No 0
BIRC3-002 ENSP00000263464
ENST00000263464
Q13489
Show all »
Show » Show » 604 68.4 No 0
BIRC3-006 ENSP00000431718
ENST00000527309
H0YCJ5
Show all »
Show » 183 20.7 No 0