ABCC2

GENERAL INFORMATION

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Gene name

ABCC2

Gene description

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Protein class

Cancer-related genes
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (duodenum, gallbladder, kidney, liver, small intestine)
GTEx:Tissue enhanced (liver)

Protein evidence

Evidence at protein level

Protein localization

High membranous staining in liver, kidney and gall bladder.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA004860 , CAB037271
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (duodenum, gallbladder, kidney, liver, small intestine)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (liver)

Organ

Expression



GENE INFORMATION

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Gene name

ABCC2 (HGNC Symbol)

Synonyms

CMOAT, cMRP, DJS, MRP2

Description

ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q24.2

Chromosome location (bp)

99782732 - 99852192

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000023839 (version 78.38)

Entrez gene

1244

UniProt

Q92887 (UniProt - Evidence at protein level)

neXtProt

NX_Q92887

Antibodypedia

ABCC2 antibodies


PROTEIN BROWSER

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ENST00000370434
 
ENST00000370449
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCC2-001 ENSP00000359478
ENST00000370449
Q92887
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Show » Show » 1545 174.2 No >9
ABCC2-002 ENSP00000359463
ENST00000370434
Q5TCZ5
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Show » 293 33.8 No 5