ABCC2

GENE INFORMATION

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Gene name

ABCC2 (HGNC Symbol)

Synonyms

CMOAT, cMRP, DJS, MRP2

Description

ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]

Chromosome

10 (Chromosome progress)

Cytoband

q24.2

Chromosome location (bp)

101542489 - 101611949

Ensembl

ENSG00000023839 (version 73.37)

Entrez gene

1244

UniProt

Q92887 (UniProt - Evidence at protein level)

neXtProt

NX_Q92887

Antibodypedia

ABCC2 antibodies
 

PROTEIN VIEW

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ABCC2-001
 
ABCC2-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCC2-001 ENSP00000359478
ENST00000370449
Q92887
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Show » Show » 1545 174.2 No >9
ABCC2-002 ENSP00000359463
ENST00000370434
Q5TCZ5
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Show » 293 33.8 No 5