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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:48.1 nTPM
HPA:48.1 nTPM
GTEx:23.9 nTPM
FANTOM5:19.6 Scaled Tags Per Million
Pig:40.1 nTPM
Mouse:26.4 nTPM
Allen mouse:1.5 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 48.1
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 47.3
2666 Male, age 74, left hemisphere 50.1
2586 Male, age 75, left hemisphere 49.8
2219 Male, age 76, both hemispheres 48.2
1870 Female, age 42, unknown 48.1
1830 Male, age 51, unknown 47.0
2828 Female, age 72, unknown 46.8
1827 Male, age 72, unknown 46.5
1833 Male, age 53, unknown 46.3
2411 Female, age 72, unknown 45.9
2019 Male, age 18, unknown 44.0
Dorsal raphe nucleus
nTPM: 47.1
2047 Male, age 72, unknown 47.9
2016 Female, age 72, unknown 47.8
1828 Male, age 53, unknown 47.1
2750 Male, age 76, both hemispheres 46.5
2298 Female, age 72, unknown 46.3
Inferior colliculus
nTPM: 47.8
2849 Male, age 72, unknown 48.6
1890 Male, age 53, unknown 47.8
1848 Female, age 42, unknown 47.6
2097 Female, age 72, unknown 47.1
Median raphe nucleus
nTPM: 46.6
2220 Male, age 76, midline 46.6
Pedunculopontine tegmental nucleus
nTPM: 47.2
2338 Male, age 61, both hemispheres 48.5
2334 Male, age 80, both hemispheres 46.6
1921 Female, age 85, both hemispheres 46.4
Periaquaductal grey, anterior
nTPM: 46.6
1947 Male, age 18, unknown 48.2
2502 Female, age 75, unknown 46.4
1795 Male, age 51, unknown 45.1
Periaquaductal grey, dorsal
nTPM: 46.2
1840 Male, age 53, unknown 47.1
2850 Male, age 76, both hemispheres 46.6
1831 Male, age 72, unknown 45.6
2464 Female, age 72, unknown 45.4
Periaquaductal grey, lateral
nTPM: 47.7
2140 Male, age 76, both hemispheres 48.9
2272 Male, age 74, both hemispheres 47.2
2053 Male, age 18, unknown 47.0
Pretectal area
nTPM: 45.8
2407 Male, age 75, both hemispheres 48.0
2825 Male, age 18, unknown 47.9
2316 Male, age 76, right hemisphere 47.8
2273 Male, age 74, both hemispheres 46.6
2224 Female, age 72, unknown 45.8
1944 Female, age 72, unknown 45.0
2007 Male, age 72, unknown 44.7
1815 Male, age 53, unknown 44.6
2667 Female, age 75, unknown 44.6
1816 Male, age 51, unknown 44.2
1817 Female, age 42, unknown 44.1
Red nucleus
nTPM: 46.3
2769 Male, age 72, unknown 49.2
2227 Male, age 72, unknown 47.9
1954 Female, age 42, unknown 47.3
2503 Female, age 72, unknown 47.1
1865 Male, age 51, unknown 47.0
2584 Male, age 75, left hemisphere 46.3
1904 Male, age 53, unknown 45.9
1821 Female, age 72, unknown 45.5
2725 Female, age 75, unknown 45.5
2785 Male, age 18, unknown 44.8
2823 Male, age 76, right hemisphere 44.7
2588 Male, age 74, left hemisphere 44.6
Substantia nigra
nTPM: 48.1
1916 Female, age 42, unknown 51.9
2699 Male, age 18, unknown 50.9
2590 Female, age 75, unknown 49.4
1941 Male, age 53, unknown 49.0
1851 Male, age 51, unknown 48.8
2665 Male, age 74, both hemispheres 48.8
2583 Male, age 75, right hemisphere 48.2
2241 Male, age 72, unknown 45.3
1889 Female, age 72, unknown 44.9
2409 Female, age 72, unknown 43.6
Superior colliculus
nTPM: 46.4
2664 Male, age 75, both hemispheres 48.3
1839 Male, age 51, unknown 47.3
2587 Male, age 74, left hemisphere 47.1
1796 Male, age 53, unknown 47.0
2668 Female, age 75, unknown 47.0
1895 Male, age 76, right hemisphere 46.0
2261 Male, age 18, unknown 46.0
1913 Female, age 42, unknown 45.7
1995 Male, age 72, unknown 45.4
2087 Female, age 72, unknown 44.3
Ventral tegmental area
nTPM: 47.5
1915 Female, age 42, unknown 50.3
1942 Male, age 51, unknown 48.1
2223 Female, age 72, unknown 47.0
2021 Male, age 53, unknown 46.9
2218 Male, age 76, both hemispheres 46.8
2410 Female, age 72, unknown 45.7

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 23.9
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 23.9
Samples: 139

Max nTPM: 55.8
Min nTPM: 7.8
Std nTPM: 8.4
Median nTPM: 23.5
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 55.8
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 54.0
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 45.9
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 45.9
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 45.0
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 42.6
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 40.0
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 38.8
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 37.9
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 36.0
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 35.9
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 35.6
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 35.5
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 33.8
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 32.6
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 32.3
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 32.2
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 31.9
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 31.8
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 31.3
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 31.1
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 30.3
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 30.1
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 29.5
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 29.4
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 29.2
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 29.1
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 29.1
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 29.0
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 29.0
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 29.0
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 28.8
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 28.5
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 28.3
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 28.3
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 28.1
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 28.1
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 27.7
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 27.5
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 27.3
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 27.1
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 27.1
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 27.1
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 26.9
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 26.9
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 26.4
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 26.3
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 26.3
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 26.2
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 26.0
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 26.0
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 25.8
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 25.7
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 25.7
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 25.3
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 25.2
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 25.1
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 25.1
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 25.0
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 24.7
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 24.6
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 24.5
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 24.4
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 24.3
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 24.1
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 24.1
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 23.7
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 23.7
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 23.5
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 23.5
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 23.0
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 22.9
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 22.9
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 22.5
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 22.2
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 22.1
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 22.0
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 21.7
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 21.5
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 21.5
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 21.5
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 21.1
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 20.9
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 20.9
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 20.8
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 20.7
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 20.7
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 20.7
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 20.3
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 20.2
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 20.0
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 20.0
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 19.8
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 19.8
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 19.8
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 19.7
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 19.6
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 19.4
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 19.2
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 19.0
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 18.8
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 18.8
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 18.7
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 18.7
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 18.3
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 18.2
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 17.9
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 17.9
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 17.6
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 17.3
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 17.3
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 17.0
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 16.8
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 16.4
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 15.8
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 15.7
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 15.6
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 15.2
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 15.1
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 15.0
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 15.0
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 14.7
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 14.6
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 14.3
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 13.9
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 13.8
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 12.9
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 12.9
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 12.8
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 12.6
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 12.4
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 12.2
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 12.0
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 11.8
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 11.4
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 10.9
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 10.3
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 9.7
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 7.8
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 19.6
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 19.6
FF:10158-103A5 76 years, female 19.6

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 40.1
Pig sample Sample description nTPM
Midbrain
nTPM: 34.5
Samples: 4

Max nTPM: 44.7
Min nTPM: 25.4
Sample A Female 33.4
Sample B Female 34.6
Sample C Male 25.4
Sample D Male 44.7
Periaqueductal gray
nTPM: 30.0
Samples: 3

Max nTPM: 33.9
Min nTPM: 25.3
Sample B Female 30.8
Sample C Male 33.9
Sample D Male 25.3
Substantia nigra
nTPM: 33.7
Samples: 4

Max nTPM: 36.5
Min nTPM: 30.8
Sample A Female 36.5
Sample B Female 36.2
Sample C Male 31.1
Sample D Male 30.8
Superior colliculi
nTPM: 40.1
Samples: 4

Max nTPM: 60.0
Min nTPM: 27.4
Sample A Female 60.0
Sample B Female 27.4
Sample C Male 27.9
Sample D Male 45.1

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 26.4
Mouse sample Sample description nTPM
Midbrain
nTPM: 26.4
Samples: 4

Max nTPM: 29.1
Min nTPM: 23.9
Sample A Male 29.1
Sample B Male 25.9
Sample C Female 23.9
Sample D Female 26.5

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 1.5
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 1.5
69407248 Antisense, RP_050414_01_C01, Mouse strain C57BL/6J (56 days, male) 1.5

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