SEC63

GENE INFORMATION

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Gene name

SEC63 (HGNC Symbol)

Synonyms

DNAJC23, ERdj2, PRO2507, SEC63L

Description

SEC63 homolog (S. cerevisiae) (HGNC Symbol)

Entrez gene summary

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

q21

Chromosome location (bp)

108188960 - 108279393

Ensembl

ENSG00000025796 (version 73.37)

Entrez gene

11231

UniProt

Q9UGP8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UGP8

Antibodypedia

SEC63 antibodies
 

PROTEIN VIEW

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SEC63-001
 
SEC63-007
 
SEC63-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SEC63-001 ENSP00000357998
ENST00000369002
Q9UGP8
Show all »
Show » Show » 760 88 No 3
SEC63-007 ENSP00000403144
ENST00000429168
A6PVC9
Show all »
Show » Show » 161 18.6 No 2
SEC63-010 ENSP00000410968
ENST00000446496
F8WB27
Show all »
Show » Show » 80 8.8 No 1