KPNA6

GENE INFORMATION

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Gene name

KPNA6 (HGNC Symbol)

Synonyms

FLJ11249, IPOA7, KPNA7, MGC17918

Description

karyopherin alpha 6 (importin alpha 7) (HGNC Symbol)

Entrez gene summary

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p35.1

Chromosome location (bp)

32573639 - 32642169

Ensembl

ENSG00000025800 (version 73.37)

Entrez gene

23633

UniProt

O60684 (UniProt - Evidence at protein level)

neXtProt

NX_O60684

Antibodypedia

KPNA6 antibodies
 

PROTEIN VIEW

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KPNA6-001
 
KPNA6-002
 
KPNA6-004
 
KPNA6-201
 
KPNA6-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KPNA6-001 ENSP00000362728
ENST00000373625
O60684
Show all »
Show » 536 60 No 0
KPNA6-002 ENSP00000474234
ENST00000471599
Show » 186 21.7 No 0
KPNA6-004 ENSP00000415677
ENST00000446515
Q5TFJ7
Show all »
Show » 321 35.5 No 0
KPNA6-201 ENSP00000444930
ENST00000537234
F5H4G7
Show all »
Show » 533 59.7 No 0
KPNA6-202 ENSP00000440609
ENST00000545542
F5GYL8
Show all »
Show » 541 60.6 No 0