PRKCH

GENE INFORMATION

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Gene name

PRKCH (HGNC Symbol)

Synonyms

PKC-L, PKCL, PRKCL

Description

protein kinase C, eta (HGNC Symbol)

Entrez gene summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. [provided by RefSeq, Jul 2008]

Chromosome

14 (Chromosome progress)

Cytoband

q23.1

Chromosome location (bp)

61654277 - 62017694

Ensembl

ENSG00000027075 (version 73.37)

Entrez gene

5583

UniProt

P24723 (UniProt - Evidence at protein level)

neXtProt

NX_P24723

Antibodypedia

PRKCH antibodies
 

PROTEIN VIEW

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 « 
 
PRKCH-001
 
PRKCH-002
 
PRKCH-005
 
PRKCH-006
 
PRKCH-014
 
PRKCH-015
 
PRKCH-017
 
PRKCH-019
 
PRKCH-020
 
PRKCH-021
 
PRKCH-022
 
PRKCH-023
 
PRKCH-027
 
PRKCH-028
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKCH-001 ENSP00000329127
ENST00000332981
P24723
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Show » Show » 683 77.8 No 0
PRKCH-002 ENSP00000450981
ENST00000555082
B4DJN5
Show all »
Show » Show » 522 59.5 No 0
PRKCH-005 ENSP00000451930
ENST00000557585
G3V4Q6
Show all »
Show » 224 25.1 No 0
PRKCH-006 ENSP00000452528
ENST00000557473
G3V5U5
Show all »
Show » 106 12.5 No 0
PRKCH-014 ENSP00000451871
ENST00000555185
G3V4L3
Show all »
Show » Show » 151 17.2 No 0
PRKCH-015 ENSP00000451789
ENST00000555542
15 1.9 No 0
PRKCH-017 ENSP00000452588
ENST00000553830
G3V5Y6
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Show » 144 16.6 No 0
PRKCH-019 ENSP00000450959
ENST00000553831
G3V304
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Show » 83 9.8 No 0
PRKCH-020 ENSP00000451793
ENST00000553726
G3V4H0
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Show » 53 5.6 No 0
PRKCH-021 ENSP00000451933
ENST00000553265
G3V4Q9
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Show » 87 10.3 No 0
PRKCH-022 ENSP00000452330
ENST00000556164
G3V5F8
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Show » 71 8.4 No 0
PRKCH-023 ENSP00000451205
ENST00000555906
G3V3E7
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Show » 73 8.6 No 0
PRKCH-027 ENSP00000452129
ENST00000557294
G3V520
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Show » 118 13.3 No 0
PRKCH-028 ENSP00000452055
ENST00000556778
G3V4X4
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Show » 130 15.2 No 0