HMGB3

GENERAL INFORMATION

? »

Gene name

HMGB3

Gene description

High mobility group box 3

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in selected tissues.

ANTIBODY RELIABILITY

? »

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. External characterization data supports antibody staining.

Data reliability

Supportive based on 1 antibody.
HPA062583
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

HMGB3 (HGNC Symbol)

Synonyms

HMG2A, HMG4, MGC90319

Description

High mobility group box 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

X

Cytoband

q28

Chromosome location (bp)

150980509 - 150990775

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000029993 (version 78.38)

Entrez gene

3149

UniProt

O15347 (UniProt - Evidence at protein level)

neXtProt

NX_O15347

Antibodypedia

HMGB3 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000325307
 
ENST00000419110
 
ENST00000430118
 
ENST00000448905
 
ENST00000455596
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HMGB3-001 ENSP00000359393
ENST00000325307
O15347
Show all »
Show » Show » 200 23 No 0
HMGB3-002 ENSP00000410354
ENST00000419110
E7ES08
Show all »
Show » Show » 188 21.4 No 0
HMGB3-003 ENSP00000405601
ENST00000455596
E7EQU1
Show all »
Show » Show » 193 22.1 No 0
HMGB3-004 ENSP00000417027
ENST00000430118
E9PES6
Show all »
Show » Show » 153 17.5 No 0
HMGB3-201 ENSP00000442758
ENST00000448905
O15347
Show all »
Show » Show » 200 23 No 0