GRN

GENE INFORMATION

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Gene name

GRN (HGNC Symbol)

Synonyms

CLN11, PCDGF, PGRN

Description

granulin (HGNC Symbol)

Entrez gene summary

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q21.31

Chromosome location (bp)

42422614 - 42430470

Ensembl

ENSG00000030582 (version 73.37)

Entrez gene

2896

UniProt

P28799 (UniProt - Evidence at protein level)

neXtProt

NX_P28799

Antibodypedia

GRN antibodies
 

PROTEIN VIEW

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 « 
 
GRN-001
 
GRN-002
 
GRN-003
 
GRN-005
 
GRN-006
 
GRN-007
 
GRN-008
 
GRN-009
 
GRN-010
 
GRN-011
 
GRN-013
 
GRN-016
 
GRN-017
 
GRN-018
 
GRN-022
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRN-001 ENSP00000053867
ENST00000053867
P28799
Show all »
Show » 593 63.5 Yes 0
GRN-002 ENSP00000467616
ENST00000589265
K7EQ05
Show all »
Show » 436 46.8 Yes 0
GRN-003 ENSP00000465673
ENST00000586443
388 41.2 No 0
GRN-005 ENSP00000466956
ENST00000589536
K7ENI2
Show all »
Show » 111 11.5 Yes 0
GRN-006 ENSP00000466271
ENST00000587109
K7ELY1
Show all »
Show » 62 6.6 Yes 0
GRN-007 ENSP00000465518
ENST00000587518
K7EK92
Show all »
Show » 136 14.3 Yes 0
GRN-008 ENSP00000466405
ENST00000593167
K7EM89
Show all »
Show » 149 15.6 Yes 0
GRN-009 ENSP00000467745
ENST00000585512
K7EQA7
Show all »
Show » 37 3.8 Yes 0
GRN-010 ENSP00000467870
ENST00000592783
K7EQK6
Show all »
Show » 142 14.9 Yes 0
GRN-011 ENSP00000467022
ENST00000591740
K7ENN1
Show all »
Show » 135 14.1 Yes 0
GRN-013 ENSP00000465375
ENST00000588143
K7EJY4
Show all »
Show » 163 17.1 Yes 0
GRN-016 ENSP00000467431
ENST00000587387
K7EPL0
Show all »
Show » 191 20.3 Yes 0
GRN-017 ENSP00000466611
ENST00000588237
K7EMR1
Show all »
Show » 172 18.1 Yes 0
GRN-018 ENSP00000468318
ENST00000586782
K7ERM2
Show all »
Show » 189 19.8 Yes 0
GRN-022 ENSP00000467837
ENST00000586242
110 11.7 No 0