ATP6V0A1

GENE INFORMATION

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Gene name

ATP6V0A1 (HGNC Symbol)

Synonyms

a1, ATP6N1, ATP6N1A, Stv1, Vph1, VPP1

Description

ATPase, H+ transporting, lysosomal V0 subunit a1 (HGNC Symbol)

Entrez gene summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q21.2

Chromosome location (bp)

40610862 - 40674629

Ensembl

ENSG00000033627 (version 73.37)

Entrez gene

535

UniProt

Q93050 (UniProt - Evidence at protein level)

neXtProt

NX_Q93050

Antibodypedia

ATP6V0A1 antibodies
 

PROTEIN VIEW

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 « 
 
ATP6V0A1-001
 
ATP6V0A1-003
 
ATP6V0A1-004
 
ATP6V0A1-005
 
ATP6V0A1-006
 
ATP6V0A1-012
 
ATP6V0A1-013
 
ATP6V0A1-014
 
ATP6V0A1-015
 
ATP6V0A1-017
 
ATP6V0A1-022
 
ATP6V0A1-023
 
ATP6V0A1-025
 
ATP6V0A1-201
 
ATP6V0A1-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP6V0A1-001 ENSP00000377415
ENST00000393829
Q93050
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Show » Show » 831 95.8 No 7
ATP6V0A1-003 ENSP00000443991
ENST00000537728
B7Z641
Show all »
Show » Show » 788 90.5 No 7
ATP6V0A1-004 ENSP00000264649
ENST00000264649
Q93050
Show all »
Show » Show » 838 96.6 No 7
ATP6V0A1-005 ENSP00000466878
ENST00000585525
B7Z2A9
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Show » Show » 794 91.2 No 7
ATP6V0A1-006 ENSP00000342951
ENST00000343619
Q93050
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Show » Show » 837 96.4 No 7
ATP6V0A1-012 ENSP00000466328
ENST00000587824
K7EM24
Show all »
Show » 130 15.4 No 0
ATP6V0A1-013 ENSP00000466290
ENST00000589213
K7ELZ6
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Show » 93 10.9 No 0
ATP6V0A1-014 ENSP00000467373
ENST00000589727
K7EPG4
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Show » 198 23 No 0
ATP6V0A1-015 ENSP00000468001
ENST00000588901
K7EQW2
Show all »
Show » 68 8.1 No 0
ATP6V0A1-017 ENSP00000466767
ENST00000592324
K7EN36
Show all »
Show » Show » 195 22.5 No 0
ATP6V0A1-022 ENSP00000466852
ENST00000588138
K7ENA1
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Show » Show » 191 21.2 No 2
ATP6V0A1-023 ENSP00000468169
ENST00000587510
Show » Show » 129 14.7 No 1
ATP6V0A1-025 ENSP00000468177
ENST00000586201
K7ERA6
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Show » Show » 188 20.8 No 1
ATP6V0A1-201 ENSP00000446377
ENST00000544137
F5H1T6
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Show » Show » 483 55.2 No 7
ATP6V0A1-202 ENSP00000444676
ENST00000546249
F5H569
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Show » Show » 837 96.3 No 7