APBA2

GENERAL INFORMATION

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Gene name

APBA2

Gene description

Amyloid beta (A4) precursor protein-binding, family A, member 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

10
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (cerebellum, cerebral cortex, hippocampus)

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
CAB037065
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebellum, cerebral cortex, hippocampus)

Organ

Expression



GENE INFORMATION

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Gene name

APBA2 (HGNC Symbol)

Synonyms

D15S1518E, HsT16821, LIN-10, MGC:14091, MINT2, X11L

Description

Amyloid beta (A4) precursor protein-binding, family A, member 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q13.1

Chromosome location (bp)

28884483 - 29118315

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000034053 (version 78.38)

Entrez gene

321

UniProt

Q99767 (UniProt - Evidence at protein level)

neXtProt

NX_Q99767

Antibodypedia

APBA2 antibodies


PROTEIN BROWSER

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ENST00000411764
 
ENST00000558206
 
ENST00000558259
 
ENST00000558330
 
ENST00000558358
 
ENST00000558402
 
ENST00000558804
 
ENST00000559709
 
ENST00000560283
 
ENST00000561069
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APBA2-001 ENSP00000453293
ENST00000558402
Q99767
Show all »
Show » Show » 749 82.5 No 0
APBA2-002 ENSP00000452722
ENST00000558330
Q99767
Show all »
Show » Show » 737 81.1 No 0
APBA2-004 ENSP00000453144
ENST00000561069
Q99767
Show all »
Show » Show » 749 82.5 No 0
APBA2-007 ENSP00000452699
ENST00000559709
Show » 4 0.5 No 0
APBA2-008 ENSP00000454001
ENST00000558804
H0YNG7
Show all »
Show » 70 7.7 No 0
APBA2-009 ENSP00000453034
ENST00000560283
H0YL28
Show all »
Show » 112 12.6 No 0
APBA2-010 ENSP00000453981
ENST00000558206
H0YNE8
Show all »
Show » 27 3 No 0
APBA2-011 ENSP00000453715
ENST00000558358
H0YMS0
Show all »
Show » 264 29.2 No 0
APBA2-201 ENSP00000409312
ENST00000411764
Q99767
Show all »
Show » Show » 737 81.1 No 0
APBA2-202 ENSP00000454171
ENST00000558259
Q99767
Show all »
Show » Show » 749 82.5 No 0