MAP2K3

GENE INFORMATION

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Gene name

MAP2K3 (HGNC Symbol)

Synonyms

MAPKK3, MEK3, MKK3, PRKMK3

Description

mitogen-activated protein kinase kinase 3 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

p11.2

Chromosome location (bp)

21187984 - 21218552

Ensembl

ENSG00000034152 (version 73.37)

Entrez gene

5606

UniProt

P46734 (UniProt - Evidence at protein level)

neXtProt

NX_P46734

Antibodypedia

MAP2K3 antibodies
 

PROTEIN VIEW

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MAP2K3-001
 
MAP2K3-002
 
MAP2K3-004
 
MAP2K3-006
 
MAP2K3-007
 
MAP2K3-011
 
MAP2K3-013
 
MAP2K3-014
 
MAP2K3-016
 
MAP2K3-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP2K3-001 ENSP00000345083
ENST00000342679
P46734
Show all »
Show » Show » 347 39.3 No 0
MAP2K3-002 ENSP00000378869
ENST00000395491
46 4.9 No 0
MAP2K3-004 ENSP00000464043
ENST00000496046
J3QR49
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Show » 173 19.5 No 0
MAP2K3-006 ENSP00000463417
ENST00000479129
J3QL77
Show all »
46 5.1 No 0
MAP2K3-007 ENSP00000463202
ENST00000483928
J3QL77
Show all »
46 5.1 No 0
MAP2K3-011 ENSP00000431203
ENST00000529517
E9PMA8
Show all »
101 10.9 No 0
MAP2K3-013 ENSP00000319139
ENST00000316920
P46734
Show all »
Show » Show » 318 36.2 No 0
MAP2K3-014 ENSP00000462178
ENST00000527123
J3KRV4
Show all »
Show » Show » 136 15 No 0
MAP2K3-016 ENSP00000434068
ENST00000526076
E9PRZ0
Show all »
Show » 160 18.2 No 0
MAP2K3-201 ENSP00000355081
ENST00000361818
P46734
Show all »
Show » Show » 318 36.2 No 0