VCL

GENE INFORMATION

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Gene name

VCL

Synonyms

Description

vinculin (HGNC Symbol)

Entrez gene summary

Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

10 (Chromosome progress)

Cytoband

q22.2

Chromosome location (bp)

75757872 - 75879918

Ensembl

ENSG00000035403 (version 73.37)

Entrez gene

7414

UniProt

P18206 (UniProt - Evidence at protein level)

neXtProt

NX_P18206

Antibodypedia

VCL antibodies
 

PROTEIN VIEW

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VCL-001
 
VCL-002
 
VCL-201
 
VCL-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VCL-001 ENSP00000361841
ENST00000372755
P18206
Show all »
Show » Show » 1066 116.7 No 0
VCL-002 ENSP00000415489
ENST00000436396
Q5JQ13
Show all »
Show » 806 87.4 No 0
VCL-201 ENSP00000211998
ENST00000211998
P18206
Show all »
Show » Show » 1134 123.8 No 0
VCL-202 ENSP00000411887
ENST00000417648
B4DTM7
Show all »
Show » 327 36.2 No 0