CUL3 protein expression summary - The Human Protein Atlas

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CUL3

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HUMAN PROTEIN ATLAS SUMMARYⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Proteinⁱ Full gene name according to HGNC.	Cullin 3
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CUL3
Tissue specificityⁱ ??The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Tissue enhanced (testis)
Tissue expression clusterⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Testis - Meiosis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed blood cell samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Brain specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category Read more	Low human brain regional specificity
Cancer prognostic summary	Gene product is not prognostic
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Protein function (UniProt)ⁱ Useful information about the protein provided by UniProt.	Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins 1. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, MACROH2A1 and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) 2, 3. BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; by mediating ubiquitination of WNK4 4, 5, 6. The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination 7, 8, 9, 10. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB 11. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation 12. The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway 13. The BCR(KLHL25) ubiquitin ligase complex is involved in translational homeostasis by mediating ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) 14. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1, leading to remodel the translational program of differentiating cells in favor of neural crest specification 15. Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 16. In concert with ATF2 and RBX1, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. The BCR(KCTD17) E3 ubiquitin ligase complex mediates ubiquitination and degradation of TCHP, a down-regulator of cilium assembly, thereby inducing ciliogenesis 17. The BCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination of KRT14, controls KRT14 levels during keratinocytes differentiation, and is essential for skin integrity 18. The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry 19. The BCR(KEAP1) E3 ubiquitin ligase complex acts as a key sensor of oxidative and electrophilic stress by mediating ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes 20, 21. As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions mediates 'Lys-48' ubiquitination and proteasomal degradation of TIAM1 22. By controlling the ubiquitination of that RAC1 guanine exchange factors (GEF), regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation 23.... show less
Biological process (UniProt)ⁱ Keywords assigned by UniProt to proteins because they are involved in a particular biological process.	Cell cycle, Cell division, Cilium biogenesis/degradation, ER-Golgi transport, Mitosis, Transport, Ubl conjugation pathway
Disease involvementⁱ Disease related keywords assigned by UniProt combined with Cancer-related genes and FDA approved drug targets Read more	Disease variant
Gene summary (Entrez)ⁱ Useful information about the gene from Entrez	This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]... show less

TISSUEⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more

Tissue expression clusterⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Testis - Meiosis (mainly)
Tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Tissue enhanced (testis)
Tissue distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Protein expressionⁱ A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation. "Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile. Read more	Ubiquitous nuclear expression.

BRAINⁱ Summary of data presented in the Brain Atlas and a representative image of mRNA expression in the human brain. The image is clickable and will redirect to more Brain Atlas data. The Brain Atlas explores the protein expression in the mammalian brain by visualization and integration of data from three mammalian species (human, pig and mouse). Transcriptomics data combined with affinity-based protein in situ localization down to single cell level is available in a brain-centric sub atlas of the Human Protein Atlas. Read more

Human regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Pig regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Mouse regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity

SINGLE CELL TYPEⁱ Summary of data presented in the Single cell Type section, with an interactive chart showing the cell type-specific mRNA expression. The chart is clickable and will redirect to more Cell Type data. This section contains information about single cell type RNA expression based on scRNAseq of human tissues. The data also covers transcriptomics analysis of human blood and cultured cell lines. Read more

Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)

TISSUE CELL TYPEⁱ

Early spermatids

Thyroid glandular cells

Classificationⁱ

Cell type enriched in 3 tissues

PATHOLOGYⁱ Summary of data presented in the Pathology section, with representative images of protein expression in cancer (left) and correlation between mRNA expression and patient survival (right). Images are clickable and redirect to pages with more Pathology data. This section contains mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more

Prognostic summary	Gene product is not prognostic
Cancer specificityⁱ Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Read more	Low cancer specificity
Cancer distributionⁱ Distribution of RNA expression in 17 cancer types is categorized as either detected in single, detected in some, detected in many, detected in all, or not detected. Read more	Detected in all

IMMUNE CELLⁱ Summary of data presented in the Immune Cell section and a representative image of mRNA expression in immune cells in the blood. The image is clickable and will redirect to more immune cell related data. The Immune Cell section contains information regarding single cell type mRNA expression profiles of protein-coding genes in various immune cells in the blood, e.g. B-cells and granulocytes. Read more

Immune cell expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Eosinophils - Unknown function (mainly)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity

BLOOD PROTEINⁱ Summary of data presented in the Blood proteins section and a representative image of the concentration in plasma and related function for the protein in plasma. The image is clickable and will redirect to more data. The Blood proteins section contains plasma levels of proteins detected in human blood and an analysis of the human secretome (including annotation of the genes predicted to be actively secreted to human blood) is also presented. Read more
Detected in blood by immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search. Read more	No (not applicable)
Detected in blood by mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.	Yes
Detected in blood by proximity extension assayⁱ Detection or not of the gene in blood, based on proximity extension assays (Olink) for a longitudinal wellness study covering 76 individuals with three visits during two years. Read more	No

SUBCELLULARⁱ Summary of data presented in the Cell Atlas and a representative image of subcellular localization. The Cell Atlas provides RNA expression data derived from RNA sequencing of a large panel of cell lines and protein localization data derived from antibody-based profiling by immunofluorescence confocal microscopy, using a subset of cell lines selected based on RNA expression. Read more

Main locationⁱ Main subcellular location(s) and reliability score(s) for the encoded protein(s) in human cells. The main location(s) may be characterized by presence in all tested cell lines and/or ihigher staining intensity compared to the potential additional location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively. Read more	Not available

CELL LINEⁱ Summary of data presented in the Cell Line section and a representative image of mRNA expression across different human cell lines. The image is clickable and will redirect to more cell line data. This section contains information regarding mRNA expression profiles of human protein-coding genes for a large variety of cell lines. Read more

Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Cell cycle regulation (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell type distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all

METABOLIC

Metabolic info	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	CUL3
Synonyms
Description	Cullin 3 (HGNC Symbol)
Chromosome	2
Cytoband	q36.2
Chromosome location (bp)	224470150 - 224585397
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7
Protein evidence	Evidence at protein level (all genes)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Ensembl	ENSG00000036257 (version 103.38)
Entrez gene	8452
UniProt	Q13618 (UniProt - Evidence at protein level)
neXtProt	NX_Q13618
Antibodypedia	CUL3 antibodies

PROTEIN BROWSERⁱ

CUL3-201

CUL3-202

CUL3-203

CUL3-204

CUL3-206

CUL3-207

CUL3-216

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CUL3-201 ENSP00000264414 ENST00000264414	Q13618 [Direct mapping] Cullin-3 A0A024R475 [Target identity:100%; Query identity:100%] Cullin 3, isoform CRA_a Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0000902 [cell morphogenesis] GO:0000922 [spindle pole] GO:0001701 [in utero embryonic development] GO:0001831 [trophectodermal cellular morphogenesis] GO:0004842 [ubiquitin-protein transferase activity] GO:0005112 [Notch binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005819 [spindle] GO:0005827 [polar microtubule] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005929 [cilium] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006513 [protein monoubiquitination] GO:0006888 [endoplasmic reticulum to Golgi vesicle-mediated transport] GO:0007049 [cell cycle] GO:0007080 [mitotic metaphase plate congression] GO:0007229 [integrin-mediated signaling pathway] GO:0007369 [gastrulation] GO:0008284 [positive regulation of cell population proliferation] GO:0016020 [membrane] GO:0016055 [Wnt signaling pathway] GO:0016192 [vesicle-mediated transport] GO:0016477 [cell migration] GO:0016567 [protein ubiquitination] GO:0017145 [stem cell division] GO:0030030 [cell projection organization] GO:0030332 [cyclin binding] GO:0031145 [anaphase-promoting complex-dependent catabolic process] GO:0031208 [POZ domain binding] GO:0031398 [positive regulation of protein ubiquitination] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0031514 [motile cilium] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032467 [positive regulation of cytokinesis] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0036126 [sperm flagellum] GO:0040016 [embryonic cleavage] GO:0042995 [cell projection] GO:0043149 [stress fiber assembly] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044346 [fibroblast apoptotic process] GO:0045842 [positive regulation of mitotic metaphase/anaphase transition] GO:0048208 [COPII vesicle coating] GO:0051301 [cell division] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0070062 [extracellular exosome] GO:0071630 [nuclear protein quality control by the ubiquitin-proteasome system] GO:0072576 [liver morphogenesis] GO:0072686 [mitotic spindle] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1901992 [positive regulation of mitotic cell cycle phase transition] Show all	768 aa 88.9 kDa	No	0
CUL3-202 ENSP00000343601 ENST00000344951	Q13618 [Direct mapping] Cullin-3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000209 [protein polyubiquitination] GO:0000922 [spindle pole] GO:0004842 [ubiquitin-protein transferase activity] GO:0005112 [Notch binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005819 [spindle] GO:0005827 [polar microtubule] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005929 [cilium] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006513 [protein monoubiquitination] GO:0006888 [endoplasmic reticulum to Golgi vesicle-mediated transport] GO:0007049 [cell cycle] GO:0007080 [mitotic metaphase plate congression] GO:0007229 [integrin-mediated signaling pathway] GO:0008284 [positive regulation of cell population proliferation] GO:0016020 [membrane] GO:0016192 [vesicle-mediated transport] GO:0016477 [cell migration] GO:0016567 [protein ubiquitination] GO:0017145 [stem cell division] GO:0030030 [cell projection organization] GO:0031145 [anaphase-promoting complex-dependent catabolic process] GO:0031208 [POZ domain binding] GO:0031398 [positive regulation of protein ubiquitination] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0031514 [motile cilium] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032467 [positive regulation of cytokinesis] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0036126 [sperm flagellum] GO:0040016 [embryonic cleavage] GO:0042995 [cell projection] GO:0043149 [stress fiber assembly] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0045842 [positive regulation of mitotic metaphase/anaphase transition] GO:0048208 [COPII vesicle coating] GO:0051301 [cell division] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0070062 [extracellular exosome] GO:0071630 [nuclear protein quality control by the ubiquitin-proteasome system] GO:0072686 [mitotic spindle] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1901992 [positive regulation of mitotic cell cycle phase transition] Show all	702 aa 81.1 kDa	No	0
CUL3-203 ENSP00000387200 ENST00000409096	Q13618 [Direct mapping] Cullin-3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000209 [protein polyubiquitination] GO:0000922 [spindle pole] GO:0004842 [ubiquitin-protein transferase activity] GO:0005112 [Notch binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005819 [spindle] GO:0005827 [polar microtubule] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005929 [cilium] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006513 [protein monoubiquitination] GO:0006888 [endoplasmic reticulum to Golgi vesicle-mediated transport] GO:0007049 [cell cycle] GO:0007080 [mitotic metaphase plate congression] GO:0007229 [integrin-mediated signaling pathway] GO:0008284 [positive regulation of cell population proliferation] GO:0016020 [membrane] GO:0016192 [vesicle-mediated transport] GO:0016477 [cell migration] GO:0016567 [protein ubiquitination] GO:0017145 [stem cell division] GO:0030030 [cell projection organization] GO:0031145 [anaphase-promoting complex-dependent catabolic process] GO:0031208 [POZ domain binding] GO:0031398 [positive regulation of protein ubiquitination] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0031514 [motile cilium] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032467 [positive regulation of cytokinesis] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0036126 [sperm flagellum] GO:0040016 [embryonic cleavage] GO:0042995 [cell projection] GO:0043149 [stress fiber assembly] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0045842 [positive regulation of mitotic metaphase/anaphase transition] GO:0048208 [COPII vesicle coating] GO:0051301 [cell division] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0070062 [extracellular exosome] GO:0071630 [nuclear protein quality control by the ubiquitin-proteasome system] GO:0072686 [mitotic spindle] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1901992 [positive regulation of mitotic cell cycle phase transition] Show all	744 aa 86.2 kDa	No	0
CUL3-204 ENSP00000386525 ENST00000409777	Q13618 [Direct mapping] Cullin-3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000209 [protein polyubiquitination] GO:0000922 [spindle pole] GO:0004842 [ubiquitin-protein transferase activity] GO:0005112 [Notch binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005819 [spindle] GO:0005827 [polar microtubule] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005929 [cilium] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006513 [protein monoubiquitination] GO:0006888 [endoplasmic reticulum to Golgi vesicle-mediated transport] GO:0007049 [cell cycle] GO:0007080 [mitotic metaphase plate congression] GO:0007229 [integrin-mediated signaling pathway] GO:0008284 [positive regulation of cell population proliferation] GO:0016020 [membrane] GO:0016192 [vesicle-mediated transport] GO:0016477 [cell migration] GO:0016567 [protein ubiquitination] GO:0017145 [stem cell division] GO:0030030 [cell projection organization] GO:0031145 [anaphase-promoting complex-dependent catabolic process] GO:0031208 [POZ domain binding] GO:0031398 [positive regulation of protein ubiquitination] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0031514 [motile cilium] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032467 [positive regulation of cytokinesis] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0036126 [sperm flagellum] GO:0040016 [embryonic cleavage] GO:0042995 [cell projection] GO:0043149 [stress fiber assembly] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0045842 [positive regulation of mitotic metaphase/anaphase transition] GO:0048208 [COPII vesicle coating] GO:0051301 [cell division] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0070062 [extracellular exosome] GO:0071630 [nuclear protein quality control by the ubiquitin-proteasome system] GO:0072686 [mitotic spindle] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1901992 [positive regulation of mitotic cell cycle phase transition] Show all	744 aa 86.2 kDa	No	0
CUL3-206 ENSP00000400935 ENST00000436172	H7C1L6 [Direct mapping] Cullin-3 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Urinary system diseases Kidney diseases Protein evidence (Ezkurdia et al 2014) Show all	GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] Show all	192 aa 22.5 kDa	No	0
CUL3-207 ENSP00000410575 ENST00000451538	H7C399 [Direct mapping] Cullin-3 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Urinary system diseases Kidney diseases Protein evidence (Ezkurdia et al 2014) Show all	GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016567 [protein ubiquitination] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031625 [ubiquitin protein ligase binding] Show all	111 aa 12.5 kDa	No	0
CUL3-216 ENSP00000477851 ENST00000617432	A0A087WTG3 [Direct mapping] Cullin-3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Urinary system diseases Kidney diseases Protein evidence (Ezkurdia et al 2014) Show all	GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016567 [protein ubiquitination] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031625 [ubiquitin protein ligase binding] Show all	342 aa 39.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.