CASR

GENE INFORMATION

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Gene name

CASR (HGNC Symbol)

Synonyms

FHH, GPRC2A, HHC, HHC1, NSHPT

Description

calcium-sensing receptor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

q21.1

Chromosome location (bp)

121902530 - 122005342

Ensembl

ENSG00000036828 (version 73.37)

Entrez gene

846

UniProt

P41180 (UniProt - Evidence at protein level)

neXtProt

NX_P41180

Antibodypedia

CASR antibodies
 

PROTEIN VIEW

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CASR-001
 
CASR-002
 
CASR-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASR-001 ENSP00000418685
ENST00000490131
P41180
Show all »
Show » Show » 1078 120.7 Yes 7
CASR-002 ENSP00000420194
ENST00000498619
E7ENE0
Show all »
Show » Show » 1088 121.8 Yes 7
CASR-201 ENSP00000296154
ENST00000296154
P41180
Show all »
Show » Show » 1078 120.7 Yes 7