CDH1

GENE INFORMATION

? »

Gene name

CDH1 (HGNC Symbol)

Synonyms

CD324, UVO, uvomorulin

Description

cadherin 1, type 1, E-cadherin (epithelial) (HGNC Symbol)

Entrez gene summary

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]

Chromosome

16 (Chromosome progress)

Cytoband

q22.1

Chromosome location (bp)

68771128 - 68869451

Ensembl

ENSG00000039068 (version 73.37)

Entrez gene

999

UniProt

P12830 (UniProt - Evidence at protein level)

neXtProt

NX_P12830

Antibodypedia

CDH1 antibodies
 

PROTEIN VIEW

? »
 
 
 
CDH1-001
 
CDH1-004
 
CDH1-005
 
CDH1-006
 
CDH1-010
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDH1-001 ENSP00000261769
ENST00000261769
P12830
Show all »
Show » Show » 882 97.5 Yes 1
CDH1-004 ENSP00000414946
ENST00000422392
Q9UII8
Show all »
Show » Show » 821 90.9 Yes 1
CDH1-005 ENSP00000454782
ENST00000566612
H3BNC6
Show all »
Show » Show » 537 59.4 Yes 0
CDH1-006 ENSP00000458139
ENST00000566510
H3BVI7
Show all »
Show » Show » 414 45.5 Yes 0
CDH1-010 ENSP00000463170
ENST00000561751
Show » Show » 155 17.5 No 0